Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal

…, R Hands, E Santelli, C Sacchetti, K Wakabayashi… - Science …, 2020 - science.org
Fibroblast-like synoviocytes (FLS) are joint-lining cells that promote rheumatoid arthritis (RA)
pathology. Current disease-modifying antirheumatic agents (DMARDs) operate through …

[PDF][PDF] Macrophage migration inhibitory factor: a multifunctional cytokine in rheumatic diseases

…, M Sato, R Takahashi, K Wakabayashi… - …, 2010 - downloads.hindawi.com
Macrophage migration inhibitory factor (MIF) was originally identified in the culture medium
of activated T lymphocytes as a soluble factor that inhibited the random migration of …

[HTML][HTML] Eotaxin-1/CCL11 is involved in cell migration in rheumatoid arthritis

K Wakabayashi, T Isozaki, Y Tsubokura, S Fukuse… - Scientific Reports, 2021 - nature.com
Eotaxin-1 (CCL11) induces the migration of different leukocyte types by interacting with
CCR3. In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) are pathogenic effectors …

Correlation of CX3CL1 and CX3CR1 levels with response to infliximab therapy in patients with rheumatoid arthritis

…, M Matsunawa, R Takahashi, K Wakabayashi… - The Journal of …, 2009 - jrheum.org
Objective. To examine the relation between serum chemokine levels and patient responsiveness
to infliximab, and the influence of infliximab administration on serum chemokine levels. …

Serum β2-microglobulin level is a useful indicator of disease activity and hemophagocytic syndrome complication in systemic lupus erythematosus and adult-onset …

K Wakabayashi, S Inokuma, E Matsubara, K Onishi… - Clinical …, 2013 - Springer
This study demonstrates whether serum β 2 -microglobulin (β 2 -MG) level can be an indicator
of the status of systemic lupus erythematosus (SLE) and adult-onset Still’s disease (AOSD)…

Relevance of the CX3CL1/fractalkine-CX3CR1 pathway in vasculitis and vasculopathy

T Kasama, K Wakabayashi, M Sato, R Takahashi… - Translational …, 2010 - Elsevier
The clinical presentation of systemic vasculitis can vary widely and include skin disorders,
neuropathy, eye symptoms, and systemic inflammation. The precise molecular mechanisms …

[HTML][HTML] RPTPα phosphatase activity is allosterically regulated by the membrane-distal catalytic domain

Y Wen, S Yang, K Wakabayashi, MND Svensson… - Journal of Biological …, 2020 - ASBMB
Receptor-type protein tyrosine phosphatase α (RPTPα) is an important positive regulator of
SRC kinase activation and a known promoter of cancer growth, fibrosis, and arthritis. The …

Expression of angiopoietin-1 in osteoblasts and its inhibition by tumor necrosis factor-alpha and interferon-gamma

…, T Isozaki, T Odai, M Matsunawa, K Wakabayashi… - Translational …, 2007 - Elsevier
Angiogenesis is a crucial component of bone remodeling under both normal and
pathophysiological conditions. Among the various mediators that regulate the angiogenic process is …

Clinical features of hemophagocytic syndrome in patients with dermatomyositis

N Yajima, K Wakabayashi, T Odai, T Isozaki… - The Journal of …, 2008 - jrheum.org
Objective To investigate the clinical features of patients with dermatomyositis (DM) complicated
by hemophagocytic syndrome (HPS). Methods Twenty-four patients diagnosed with DM …

Eosinophilic gastroenteritis due to cow's milk allergy presenting with acute pancreatitis

…, S Matsukura, M Adachi, K Wakabayashi… - International archives of …, 2012 - karger.com
Eosinophilic gastroenteritis (EGE) is characterized by eosinophilic infiltration of the
digestive organs, most commonly of the stomach and the duodenum. Symptoms of EGE are …