Preclinical rheumatoid arthritis: progress toward prevention
K Mankia, P Emery - Arthritis & rheumatology, 2016 - Wiley Online Library
Starting therapy early leads to better outcomes for rheumatoid arthritis (RA) patients. Early
initiation of disease-modifying treatments is associated with less joint damage and increased …
initiation of disease-modifying treatments is associated with less joint damage and increased …
Prevalence of periodontal disease and periodontopathic bacteria in anti–cyclic citrullinated protein antibody–positive at-risk adults without arthritis
K Mankia, Z Cheng, T Do, L Hunt, J Meade… - JAMA network …, 2019 - jamanetwork.com
Importance The prevalence of periodontitis is increased in patients with rheumatoid arthritis (RA)
and periodontopathic bacteria can citrullinate proteins. Periodontitis may, therefore, be …
and periodontopathic bacteria can citrullinate proteins. Periodontitis may, therefore, be …
Periodontal disease and periodontal bacteria as triggers for rheumatoid arthritis
Z Cheng, J Meade, K Mankia, P Emery… - Best practice & research …, 2017 - Elsevier
There is an epidemiological association between periodontitis and rheumatoid arthritis (RA),
which is hypothesised to lead to enhanced generation of RA-related autoantibodies that …
which is hypothesised to lead to enhanced generation of RA-related autoantibodies that …
Palindromic rheumatism as part of the rheumatoid arthritis continuum
K Mankia, P Emery - Nature Reviews Rheumatology, 2019 - nature.com
Palindromic rheumatism is a distinctive syndrome that has a long-recognized association with
rheumatoid arthritis (RA). Palindromic rheumatism is characterized by intermittent flares of …
rheumatoid arthritis (RA). Palindromic rheumatism is characterized by intermittent flares of …
[HTML][HTML] The role of the microbiome in driving RA-related autoimmunity
CM Rooney, K Mankia, P Emery - Frontiers in cell and developmental …, 2020 - frontiersin.org
Once referred to as “normal commensal flora” the human microbiome plays an integral role
between health and disease. The host mucosal surface replete with a multitude of immune …
between health and disease. The host mucosal surface replete with a multitude of immune …
[HTML][HTML] The role of musculoskeletal ultrasound in the rheumatoid arthritis continuum
A Di Matteo, K Mankia, M Azukizawa… - Current rheumatology …, 2020 - Springer
Purpose of Review Rheumatoid arthritis (RA) is no longer considered a fixed phenotype but
rather a disease continuum. This review outlines the current and potential value of applying …
rather a disease continuum. This review outlines the current and potential value of applying …
[HTML][HTML] IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma
Abstract Treatment with immune checkpoint blockade (ICB) frequently triggers immune-related
adverse events (irAEs), causing considerable morbidity. In 214 patients receiving ICB for …
adverse events (irAEs), causing considerable morbidity. In 214 patients receiving ICB for …
Dysbiosis in the oral microbiomes of anti-CCP positive individuals at risk of developing rheumatoid arthritis
Z Cheng, T Do, K Mankia, J Meade, L Hunt… - Annals of the …, 2021 - ard.bmj.com
Objectives An increased prevalence of periodontitis and perturbation of the oral microbiome
has been identified in patients with rheumatoid arthritis (RA). The periodontal pathogen …
has been identified in patients with rheumatoid arthritis (RA). The periodontal pathogen …
EULAR points to consider for conducting clinical trials and observational studies in individuals at risk of rheumatoid arthritis
K Mankia, HJ Siddle, A Kerschbaumer… - Annals of the …, 2021 - ard.bmj.com
Background Despite growing interest, there is no guidance or consensus on how to conduct
clinical trials and observational studies in populations at risk of rheumatoid arthritis (RA). …
clinical trials and observational studies in populations at risk of rheumatoid arthritis (RA). …
Determining in which pre-arthritis stage HLA-shared epitope alleles and smoking exert their effect on the development of rheumatoid arthritis
…, L Van Boheemen, M Verstappen, K Mankia… - Annals of the …, 2022 - ard.bmj.com
Objectives The human leukocyte antigen-shared epitope (HLA-SE) alleles and smoking are
the most prominent genetic and environmental risk factors for rheumatoid arthritis (RA). …
the most prominent genetic and environmental risk factors for rheumatoid arthritis (RA). …