User profiles for KENNETH S. RANKIN

Kenneth Rankin

Newcastle University
Verified email at ncl.ac.uk
Cited by 5608

[PDF][PDF] Characterization of the cartilage DNA methylome in knee and hip osteoarthritis

…, MJ Barter, R Refaie, KS Rankin… - Arthritis & …, 2014 - Wiley Online Library
Objective The aim of this study was to characterize the genome‐wide DNA methylation profile
of chondrocytes from knee and hip cartilage obtained from patients with osteoarthritis (OA) …

[HTML][HTML] Macrophage proliferation distinguishes 2 subgroups of knee osteoarthritis patients

…, AG Pratt, KS Rankin, JD Isaacs, MA Haniffa, S Milling… - JCI insight, 2019 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a leading cause of disability, globally. Despite an emerging role for
synovial inflammation in OA pathogenesis, attempts to target inflammation therapeutically have …

[HTML][HTML] Surgical advances in osteosarcoma

…, Z Gamie, T Beckingsale, KM Ghosh, KS Rankin - Cancers, 2021 - mdpi.com
Simple Summary Osteosarcoma (OS) is the most common bone cancer in children. OS most
commonly arises in the legs, but can arise in any bone, including the spine, head or neck. …

Of dogs and men: comparative biology as a tool for the discovery of novel biomarkers and drug development targets in osteosarcoma

KS Rankin, M Starkey, J Lunec… - Pediatric blood & …, 2012 - Wiley Online Library
The similarities between human and canine osteosarcoma with regard to histology, biological
behavior and molecular genetic alterations suggest that the dog provides a supplementary …

Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients

…, JYK Lee, KS Rankin, S Lozano-Calderon… - Nature Biomedical …, 2023 - nature.com
The surgical resection of solid tumours can be enhanced by fluorescence-guided imaging.
However, variable tumour uptake and incomplete clearance of fluorescent dyes reduces the …

Intraoperative near-infrared fluorescence (NIR) imaging with indocyanine green (ICG) can identify bone and soft tissue sarcomas which may provide guidance for …

…, KM Ghosh, M Ragbir, KS Rankin - Annals of …, 2021 - journals.lww.com
Background: Complete excision of sarcomas to maximize function without compromising
the oncological outcome can be challenging. The aim of this study was to investigate the …

Matrix metalloproteinase‐13 is fully activated by neutrophil elastase and inactivates its serpin inhibitor, alpha‐1 antitrypsin: Implications for osteoarthritis

…, S Janciauskiene, R Refaie, KS Rankin… - The FEBS …, 2022 - Wiley Online Library
Matrix metalloproteinase‐13 (MMP‐13) is a uniquely important collagenase that promotes
the irreversible destruction of cartilage collagen in osteoarthritis (OA). Collagenase activation …

[HTML][HTML] Intraoperative near-infrared fluorescence guided surgery using indocyanine green (ICG) for the resection of sarcomas may reduce the positive margin rate: An …

…, D Saleh, P Dildey, S Gupta, M Ragbir, KS Rankin - Cancers, 2021 - mdpi.com
Simple Summary Sarcomas are rare cancers that can arise all over the body, with many
occurring in younger people. Treatment is usually based around surgery to remove the tumour. It …

Synthesis and In Vivo Evaluation of a Site-specifically Labeled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas

…, CD Chan, S Luli, HJ Blair, KS Rankin… - Bioconjugate …, 2022 - ACS Publications
Bone sarcomas are devastating primary bone cancers that mostly affect children, young adults,
and the elderly. These aggressive tumors are associated with poor survival, and surgery …

Layer-by-layer coatings of collagen–hyaluronic acid loaded with an antibacterial manuka honey bioactive compound to fight metallic implant infections

…, I Khan, L Pontiroli, KS Rankin… - … Applied Materials & …, 2023 - ACS Publications
Implant-associated severe infections can result in catastrophic implant failures; thus, advanced
antibacterial coatings are needed to combat infections. This study focuses on harnessing …