Castleman disease (CD) describes a group of heterogeneous hematologic disorders with
characteristic histopathological features. CD can present with unicentric or multicentric (MCD) …

Interleukin 6 (IL6) is a pleiotropic cytokine with a wide range of biological activities. IL6 transgene
into mice gives rise to the abnormalities such as hyper-γ-globulinaemia, thrombocytosis…

Tocilizumab (TCZ) is an interleukin-6 (IL-6) inhibitor used for the treatment of rheumatoid
arthritis (RA). It was developed in 2008, and its effectiveness is supported by evidence from all …

Objective Interleukin‐6 (IL‐6) is a pleiotropic cytokine that regulates the immune response,
inflammation, and hematopoiesis. Overproduction of IL‐6 plays pathologic roles in …

The pro-inflammatory cytokine interleukin (IL)-6 (refs. 1–5) can bind to cells lacking the IL-6
receptor (IL-6R) when it forms a complex with the soluble IL-6R (sIL-6R)(trans signaling) 5, 6, …

Castleman's disease is a syndrome consisting of giant lymph node hyperplasia with plasma
cell infiltration, fever, anemia, hypergammaglobulinemia, and an increase in the plasma …

… Yoshizaki and Nishimoto have received consulting fees and a research grant for other …
Yoshizaki and Nishimoto have received consulting fees and a research grant for other projects …

The signalling pathway that comprises JAK kinases and STAT proteins (for signal transducer
and activator of transcription) is important for relaying signals from various cytokines …

… Kishimoto and K. Yoshizaki contributed to the conception of the study and worked as
coordinators of the clinical trial. KA made a histologic diagnosis of each patient's lymph node, which …

Background & Aims: Interleukin-6 (IL-6) regulates immune response and inflammation. We
carried out a pilot placebo-controlled study to investigate the efficacy, pharmacokinetics, and …