Monitoring tryptophan metabolism in chronic immune activation
K Schröcksnadel, B Wirleitner, C Winkler, D Fuchs - Clinica chimica acta, 2006 - Elsevier
The essential amino acid tryptophan is a constituent of proteins and is also a substrate for
two important biosynthetic pathways: the generation of neurotransmitter 5-hydroxytryptamine (…
two important biosynthetic pathways: the generation of neurotransmitter 5-hydroxytryptamine (…
Chronic immune stimulation correlates with reduced phenylalanine turnover
G Neurauter, K Schrocksnadel… - Current drug …, 2008 - ingentaconnect.com
Neurospychiatric symptoms like mood changes and depression are common in patients with
chronic inflammatory disorders such as infections, autoimmune diseases or cancer. The …
chronic inflammatory disorders such as infections, autoimmune diseases or cancer. The …
Neopterin, a prognostic marker in human malignancies
Increased neopterin concentrations are established in patients with an activated cellular (=
Th1-type) immune response which includes allograft rejection, viral infection and …
Th1-type) immune response which includes allograft rejection, viral infection and …
Malondialdehyde, carbonyl proteins and albumin-disulphide as useful oxidative markers in mild cognitive impairment and Alzheimer's disease
…, M Lamprecht, K Schroecksnadel… - Free radical …, 2008 - Taylor & Francis
The question arises as to whether oxidative stress has a primary role in neurodegeneration
or is a secondary end-stage epiphenomenon. The aim of the present study was to determine …
or is a secondary end-stage epiphenomenon. The aim of the present study was to determine …
Increasing production of homocysteine and neopterin and degradation of tryptophan with older age
B Frick, K Schroecksnadel, G Neurauter, F Leblhuber… - Clinical …, 2004 - Elsevier
Objectives: Aging is associated with an increased frequency of abnormal immune system
function, which may cause infections, autoimmune diseases, and cardiovascular or …
function, which may cause infections, autoimmune diseases, and cardiovascular or …
Crucial role of interferon-γ and stimulated macrophages in cardiovascular disease
K Schroecksnadel, B Frick, C Winkler… - Current vascular …, 2006 - ingentaconnect.com
Inflammation and immune activation are crucially involved in the pathogenesis of atherosclerosis
and cardiovascular disease. Accordingly, markers of inflammation such as fibrinogen, …
and cardiovascular disease. Accordingly, markers of inflammation such as fibrinogen, …
Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations
M Ploder, G Neurauter, A Spittler, K Schroecksnadel… - Amino acids, 2008 - Springer
Increased blood concentrations of phenylalanine in patients with trauma and sepsis are
common but unexplained. We examined the potential relationship between serum …
common but unexplained. We examined the potential relationship between serum …
Tryptophan degradation increases with stage in patients with rheumatoid arthritis
K Schroecksnadel, C Winkler, C Duftner… - Clinical …, 2006 - Springer
Immune system activation is known to be involved in the progression of rheumatoid arthritis (RA).
The proinflammatory cytokine interferon-γ in various cells, including monocytes, …
The proinflammatory cytokine interferon-γ in various cells, including monocytes, …
Neopterin in HIV-1 infection
B Wirleitner, K Schroecksnadel, C Winkler… - Molecular immunology, 2005 - Elsevier
Neopterin is well established as a reliable marker in HIV-1 infection. Neopterin concentrations
measured in urine or serum indicate sensitively the course and progression of the disease …
measured in urine or serum indicate sensitively the course and progression of the disease …
Increased degradation of tryptophan in blood of patients with rheumatoid arthritis.
K Schroecksnadel, S Kaser, M Ledochowski… - The Journal of …, 2003 - jrheum.org
OBJECTIVE: Activation of the enzyme indoleamine-(2,3)-dioxygenase (IDO) by interferon (IFN)-g
leads to enhanced tryptophan conversion to kynurenine. In consequence of chronic …
leads to enhanced tryptophan conversion to kynurenine. In consequence of chronic …