BACKGROUND: A pulmonary metastasectomy for colorectal carcinoma is a generally accepted
procedure, although several prognostic predictors have been reported. The aim of this …

Objectives: Randomized trials have suggested that hypertonic saline solutions may be superior
to mannitol for the treatment of elevated intracranial pressure, but their impact on clinical …

Coronaviruses have large positive-strand RNA genomes that are 5′ capped and 3′
polyadenylated. The 5′-terminal two-thirds of the genome contain two open reading frames (…

Background Patients with non-small-cell lung cancer harbouring mutations in the epidermal
growth factor receptor (EGFR) gene respond well to the EGFR-specific tyrosine kinase …

Background In single-group studies, chromosomal rearrangements of the anaplastic lymphoma
kinase gene (ALK) have been associated with marked clinical responses to crizotinib, an …

Background The efficacy of the ALK inhibitor crizotinib as compared with standard
chemotherapy as first-line treatment for advanced ALK-positive non–small-cell lung cancer (NSCLC) …

Purpose: To evaluate the efficacy and tolerability of two doses of gefitinib (Iressa [ZD1839];
AstraZeneca, Wilmington, DE), a novel epidermal growth factor receptor tyrosine kinase …

ContextIn patients with brain metastases, it is unclear whether adding up-front whole-brain
radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on …

Background Tumour mutational burden (TMB) has been retrospectively correlated with
response to immune checkpoint blockade. We prospectively explored the association of high …

Background Human epidermal growth factor receptor 2 (HER2)–targeted therapies have
not been approved for patients with non–small-cell lung cancer (NSCLC). The efficacy and …