A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Objective. Polymorphisms and haplotypes of the peptidylarginine deiminase type 4 gene (PADI4)
have been reported to be associated with rheumatoid arthritis (RA) in a Japanese …

Real-world evidence, based on real-world data from routine clinical treatment, is becoming
increasingly important for providing high-quality medical care. Large-scale cohort studies can …

… The gel was aged at room temperature for 24 h and then dried at 333 K in air for 24 h. The
surfactants were removed from the dried products by calcination at 873 K in air for 3 h. We …

Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation.
We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese …

Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology.
Here, through a genome-wide association study of rheumatoid arthritis, we identified a …

Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry
genetic research of RA promises to improve power to detect genetic signals, fine-…

Objective: Structural brain imaging studies in obsessive-compulsive disorder (OCD) have
produced inconsistent findings. This may be partially due to limited statistical power from …

Management of rheumatoid arthritis (RA) has improved over the last 10 years. These
changes have been monitored in the Institute of Rheumatology, Rheumatoid Arthritis (IORRA) …

Anti-tumor necrosis factor alpha (anti-TNF) biologic therapy is a widely used treatment for
rheumatoid arthritis (RA). It is unknown why some RA patients fail to respond adequately to anti…