Molecular identification of a renal urate–anion exchanger that regulates blood urate levels

…, Y Kikuchi, T Oda, K Ichida, T Hosoya, K Shimokata… - Nature, 2002 - nature.com
… Urate exists primarily as a weak acid at physiological pH with apK a value of 5.75 (ref. 10);
therefore, the structure of the urate transporter should be similar to that of members of the …

[HTML][HTML] Mutations associated with functional disorder of xanthine oxidoreductase and hereditary xanthinuria in humans

K Ichida, Y Amaya, K Okamoto, T Nishino - International journal of …, 2012 - mdpi.com
… The reported k cat value of NO formation is 0.17 s −1 at 37 C with NADH as an electron
donor under anaerobic conditions [30], ie, less than 1% of k cat for xanthine oxidizing activity (k

[HTML][HTML] Decreased extra-renal urate excretion is a common cause of hyperuricemia

K Ichida, H Matsuo, T Takada, A Nakayama… - Nature …, 2012 - nature.com
… The risk allele frequency of Q126X (risk allele, X) and Q141K (risk allele, K), among 644
male outpatients with hyperuricemia … K. Ichida, HM and TT contributed equally to this work. …

4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

K Uchida - Progress in lipid research, 2003 - Elsevier
… adducts were demonstrated to account for <10% of the total protein carbonyl groups
associated with the modified proteins that accumulate in liver hepatocytes of old rats (Uchida and …

Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population

H Matsuo, T Takada, K Ichida, T Nakamura… - Science translational …, 2009 - science.org
… transport of urate were a K m of 8.24 ± 1.44 mM and a V max (maximum velocity) of 6.96
± 0.89 nmol/min per milligram of protein (Fig. 1C). The calculated K m value exceeded the …

Samples returned from the asteroid Ryugu are similar to Ivuna-type carbonaceous meteorites

…, H Hidaka, H Homma, P Hoppe, GR Huss, K Ichida… - Science, 2022 - science.org
Carbonaceous meteorites are thought to be fragments of C-type (carbonaceous) asteroids.
Samples of the C-type asteroid (162173) Ryugu were retrieved by the Hayabusa2 spacecraft. …

[HTML][HTML] Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans

N Anzai, K Ichida, P Jutabha, T Kimura, E Babu… - Journal of biological …, 2008 - ASBMB
… GLUT9-expressed Xenopus oocytes mediated saturable urate transport (K m : 365 ± 42 μm).
The transport was Na + -independent and enhanced at high concentrations of extracellular …

A rare case of idiopathic hypoparathyroidism with varied neurological manifestations

S Abe, K Tojo, K Ichida, T Shigematsu… - Internal …, 1996 - jstage.jst.go.jp
… U rin aly sis ' Al k al in e ph os ph a ta se … 33) Kashihara K, Yabuki S. Unilateral choreic
movements in idiopathic hypoparathyroidism. NoToShinkei 44: 477, 1992 (in Japanese, abstract …

Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion

K Ichida, M Hosoyamada, I Hisatome… - Journal of the …, 2004 - journals.lww.com
ABSTRACT. Renal hypouricemia is an inherited and heterogeneous disorder characterized
by increased urate clearance (CUA). The authors recently established that urate was …

[HTML][HTML] Prognosis in IgA nephropathy: 30-year analysis of 1,012 patients at a single center in Japan

…, H Kataoka, M Itabashi, T Takei, K Uchida, K Nitta - Plos one, 2014 - journals.plos.org
Background Little is known about the long-term prognosis of patients with IgA nephropathy (IgAN).
Methods This retrospective cohort analysis evaluated clinical and histological findings …