The natural history of idiopathic pulmonary fibrosis (IPF) has been characterized as a steady,
predictable decline in lung function over time. Recent evidence suggests that some …

Acute exacerbation of idiopathic pulmonary fibrosis has been defined as an acute, clinically
significant, respiratory deterioration of unidentifiable cause. The objective of this …

Immune checkpoint inhibitors (ICI) targeting CTLA-4 and the PD-1/PD-L1 axis have shown
unprecedented clinical activity in several types of cancer and are rapidly transforming the …

Answer questions and earn CME/CNE To update the melanoma staging system of the
American Joint Committee on Cancer (AJCC) a large database was assembled comprising >…

This document is an international evidence-based guideline on the diagnosis and management
of idiopathic pulmonary fibrosis, and is a collaborative effort of the American Thoracic …

Purpose To revise the staging system for cutaneous melanoma on the basis of data from an
expanded American Joint Committee on Cancer (AJCC) Melanoma Staging Database. …

Background: In 2002 the American Thoracic Society/European Respiratory Society (ATS/ERS)
classification of idiopathic interstitial pneumonias (IIPs) defined seven specific entities, …

Background Phase 1 and 2 clinical trials of the BRAF kinase inhibitor vemurafenib (PLX4032)
have shown response rates of more than 50% in patients with metastatic melanoma with …

To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied
single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, profiling …

Background The identification of somatic mutations in the gene encoding the serine–threonine
protein kinase B-RAF (BRAF) in the majority of melanomas offers an opportunity to test …