Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-inflammatory
effects, they have been amongst the most widely used and effective treatments to …

Worldwide, COPD is in the spotlight, since the high prevalence, morbidity and mortality
present challenges for healthcare systems. The inconsistent use of terminology for COPD, and …

Background This study aims to review the literature regarding the barriers to sampling,
recruitment, participation, and retention of members of socioeconomically disadvantaged groups …

Interleukin-1β (IL-1β)-converting enzyme cleaves the IL-1β precursor to mature IL-1β, an
important mediator of inflammation. The identification of the enzyme as a unique cysteine …

Catalytic protein subunits of telomerase from the ciliateEuplotes aediculatus and the yeast
Saccharomyces cerevisiae contain reverse transcriptase motifs. Here the homologous genes …

… of a fluorogenic substrate, Ac-WEHD-AMC, that is cleaved 50-fold more efficiently than that
previously believed to be optimal for this enzyme, with a second order rate constant (k cat /K …

… in 1:1 acetonitrile/acetic acid cooled to temperatures well below the freezing point of
acetic acid reduced ¡3-hydroxy ketone 2 with excellent diastereoselectivity (entry K). These …

Background. Sit-to-stand (STS) performance is often used as a measure of lower-limb
strength in older people and those with significant weakness. However, the findings of recent …

Background: Treatment of moderate or severe chronic obstructive pulmonary disease (COPD)
with combinations of inhaled corticosteroids, long-acting β-agonists, and long-acting …

… These rate constants predict K D values (K D = k off /k on ) of 440 and 32 nM, respectively, …
and found to be completely inactive in vitro (K i > 100 × K D for EZE-gluc in all species) and in …