… the plating efficiency in this experiment, we purified CMPs from transgenic mice which have
enforced expression of the anti-apoptotic bcl-2 gene in all haematopoietic cells via the H-2 k …

Prospective isolation of hematopoietic stem and progenitor cells has identified the lineal
relationships among all blood-cell types and has allowed their developmental mechanisms to …

Drought‐affected plants experience more than just desiccation of their organs due to water
deficit. Plants transpire 1000 times more molecules of water than of CO 2 fixed by …

Mice lacking functional IL-7 or IL-7Rα genes are severely deficient in developing thymocytes,
T cells, and B cells. IL-7 and IL-7 receptor functions are believed to result in lymphoid cell …

To elucidate the molecular mechanisms underlying normal and malignant hematopoietic
development, it is critical to identify developmental intermediates for each lineage downstream …

The existence of a common lymphoid progenitor that can only give rise to T cells, B cells,
and natural killer (NK) cells remains controversial and constitutes an important gap in the …

Dendritic cells (DCs) are critical in both initiating adaptive immune responses and maintaining
tolerance to self antigens. These apparently contradictory roles have been suggested to …

Acute myeloid leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an
ultimate therapeutic target for AML. Here we identified T cell immunoglobulin mucin-3 (TIM-3…

Acute myelogenous leukemia (AML) is the most common adult leukemia, characterized by
the clonal expansion of immature myeloblasts initiating from rare leukemic stem (LS) cells 1 , …

D-type cyclins (cyclins D1, D2, and D3) are regarded as essential links between cell environment
and the core cell cycle machinery. We tested the requirement for D-cyclins in mouse …