Routine use of quantitative disease activity measurements among US rheumatologists: implications for treat-to-target management strategies in rheumatoid arthritis
…, L Chen, MI Danila, KG Saag, KL Parham… - The Journal of …, 2018 - jrheum.org
Objective. The aim of our study was to examine why real-world practices and attitudes regarding
quantitative measurements of rheumatoid arthritis (RA) have received limited attention. …
quantitative measurements of rheumatoid arthritis (RA) have received limited attention. …
Vitamin C prophylaxis promotes oxidative lipid damage during surgical ischemia–reperfusion
…, S Raman, J McEneny, IS Young, KL Parham… - Free Radical Biology …, 2006 - Elsevier
Reactive oxygen species (ROS) have been implicated in the cellular membrane damage
and postoperative morbidity associated with obligatory ischemia–reperfusion (IR) during …
and postoperative morbidity associated with obligatory ischemia–reperfusion (IR) during …
Promoter analysis of human corticotropin-releasing factor (CRF) type 1 receptor and regulation by CRF and urocortin
KL Parham, S Zervou, E Karteris, RD Catalano… - …, 2004 - academic.oup.com
We report the full genomic organization of the human gene for the corticotropin-releasing
factor (CRF) receptor type 1 (CRFR1), with complete mapping of exons 1–14. The 5′ flanking …
factor (CRF) receptor type 1 (CRFR1), with complete mapping of exons 1–14. The 5′ flanking …
Prevalence of mutations leading to complete C6 deficiency (C6Q0) in the Western Cape, South Africa and detection of novel mutations leading to C6Q0 in an Irish …
KL Parham, A Roberts, A Thomas, R Würzner… - Molecular …, 2007 - Elsevier
Complement component C6 is one of five terminal complement components incorporated
into the membrane attack complex. Complete deficiency of C6 (C6Q0) leads to an increased …
into the membrane attack complex. Complete deficiency of C6 (C6Q0) leads to an increased …
A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature
…, KL McQueen, LA Guethlein, P Parham… - Blood, The Journal …, 2007 - ashpublications.org
How receptor acquisition correlates with the functional maturation of natural killer (NK) cells
is poorly understood. We used quantitative real-time polymerase chain reaction (PCR) …
is poorly understood. We used quantitative real-time polymerase chain reaction (PCR) …
Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes
Natural killer (NK) cells contribute to the essential functions of innate immunity and reproduction.
Various genes encode NK cell receptors that recognize the major histocompatibility …
Various genes encode NK cell receptors that recognize the major histocompatibility …
Donor–recipient combinations of group A and B KIR haplotypes and HLA class I ligand affect the outcome of HLA-matched, sibling donor hematopoietic cell …
…, LA Guethlein, R Wong, B Sanjanwala, P Parham - Human immunology, 2007 - Elsevier
The influence of donor and recipient killer immunoglobulin-like receptor (KIR) genotype on
the outcome of hematopoietic cell transplantation between human leukocyte antigen (HLA)–…
the outcome of hematopoietic cell transplantation between human leukocyte antigen (HLA)–…
[HTML][HTML] Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis
KA Parham, JR Zebol, KL Tooley, WY Sun… - The FASEB …, 2015 - ncbi.nlm.nih.gov
Sphingosine 1-phosphate (S1P) is a bioactive lipid that can function both extracellularly and
intracellularly to mediate a variety of cellular processes. Using lipid affinity matrices and a …
intracellularly to mediate a variety of cellular processes. Using lipid affinity matrices and a …
Sequences of 95 human MHC haplotypes reveal extreme coding variation in genes other than highly polymorphic HLA class I and II
…, L Abi-Rached, M Ronaghi, P Parham - Genome …, 2017 - genome.cshlp.org
The most polymorphic part of the human genome, the MHC, encodes over 160 proteins of
diverse function. Half of them, including the HLA class I and II genes, are directly involved in …
diverse function. Half of them, including the HLA class I and II genes, are directly involved in …
Variable receptors controlling activation and inhibition of NK cells
KL McQueen, P Parham - Current opinion in immunology, 2002 - Elsevier
NK cells are important effector lymphocytes of innate immunity; they kill infected cells and
produce cytokines that stimulate other immune effects. Once considered relatively …
produce cytokines that stimulate other immune effects. Once considered relatively …