Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays
an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage …

Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage
in the presence of altered joint mechanics and chondrocyte death, but the connection …

Objective To investigate whether cartilage degeneration is prevented or minimized following
intraarticular injections of lubricin derived from human synoviocytes in culture, recombinant …

Restoration of riparian forests has been promoted as a means of mitigating urban impacts
on stream ecosystems. However, conventional urban stormwater drainage may diminish the …

Background: Lubricin, or proteoglycan 4 (PRG4), is a glycoprotein responsible for joint boundary
lubrication. PRG4 has been shown previously to be down-regulated after traumatic joint …

To identify the molecular pathophysiology present in early post‐traumatic osteoarthritis (PTOA),
the transcriptional profile of articular cartilage and its response to surgical PTOA …

Deficiency of PRG4 (lubricin), the boundary lubricant in mammalian joints, contributes to
increased joint friction accompanied by superficial and upper intermediate zone chondrocyte …

Objective. Symptomatic osteoarthritis (OA) is a common painful disease with limited treatment
options. A rising number of patients with OA have been treated with intraarticular injections …

… Hill and Waller contributed equally to this work. Drs. Cui, Warman, and Jay receive royalties
… Waller KA, Zhang LX, Fleming BC, Jay GD. Preventing friction-induced chondrocyte …

To determine the transcriptional profile of synovium during the molecular phase of post‐traumatic
osteoarthritis, anterior cruciate ligament transections (ACL) were performed in 36 …