Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states.
Previous genetic studies have largely focused on insulin resistance in the fasting state, …

Increasing empirical evidence suggests that many genetic variants influence multiple distinct
phenotypes. When cross-phenotype effects exist, multivariate association methods that …

Insulin secretion is critical for glucose homeostasis, and increased levels of the precursor
proinsulin relative to insulin indicate pancreatic islet beta-cell stress and insufficient insulin …

Integration of genome-wide association study (GWAS) signals with expression quantitative
trait loci (eQTL) studies enables identification of candidate genes. However, evaluating …

Importance Hidradenitis suppurativa (HS) is a common and severely morbid chronic
inflammatory skin disease that is reported to be highly heritable. However, the genetic …

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes. To characterise the genetic contribution to these processes across …

Expression quantitative trait locus (eQTL) studies in human liver are crucial for elucidating
how genetic variation influences variability in disease risk and therapeutic outcomes and may …

Context: Classic galactosemia is a potentially lethal genetic disorder resulting from profound
impairment of galactose-1P uridylyltransferase (GALT). More than 80% of girls and women …

Identifying the molecular mechanisms by which genome-wide association study (GWAS)
loci influence traits remains challenging. Chromatin accessibility quantitative trait loci (caQTLs) …

Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse pathophysiological
processes 1 , 2 and molecular mechanisms that are often specific to cell type 3 , 4 . …