We have developed a new expression vector which allows efficient selection for transfectants
that express foreign genes at high levels. The vector is composed of a ubiquitously strong …

Cell fate during development is defined by transcription factors that act as molecular switches
to activate or repress specific gene expression programmes. The POU transcription factor …

Two cell lines have been established from insulinomas obtained by targeted expression of
the simian virus 40 T antigen gene in transgenic mice. These cell lines, designated MIN6 and …

γ‐aminobutyric acid (GABA)ergic neurons in the central nervous system regulate the activity
of other neurons and play a crucial role in information processing. To assist an advance in …

Endocardial cells are thought to contribute at least in part to the formation of the endocardial
cushion mesenchyme. Here, we created Tie2-Cre transgenic mice, in which expression of …

Among the nonviral techniques for gene transfer in vivo, the direct injection of plasmid DNA
into muscle is simple, inexpensive, and safe. Applications of this method have been limited …

Interleukin 6 (IL-6) has been suggested to be involved in the pathogenesis of polyclonal and
monoclonal plasma cell abnormalities. To address this possibility, transgenic mice carrying …

Phospholipase A 2 (PLA 2 ) comprises a superfamily of enzymes that hydrolyse the ester
bond of phospholipids at the sn-2 position 1 , 2 , 3 . Among the members of this superfamily, …

Most prostate cancers (PCs) become resistant to combined androgen blockade therapy with
surgical or medical castration and antiandrogens after several years. Some of these …

The Mesp1 gene encodes the basic HLH protein MesP1 which is expressed in the mesodermal
cell lineage during early gastrulation. Disruption of the Mesp1 gene leads to aberrant …