User profiles for Joseph Loscalzo
 | Joseph LoscalzoProfessor of Medicine, Harvard Medical School Verified email at partners.org Cited by 144202 |
Network medicine: a network-based approach to human disease
Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …
A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds
CONGENERS of nitrogen monoxide (NO) are neuroprotective and neurodestructive 1– 7.
To address this apparent paradox, we considered the effects on neurons of compounds …
To address this apparent paradox, we considered the effects on neurons of compounds …
Homocysteine and atherothrombosis
GN Welch, J Loscalzo - New England journal of medicine, 1998 - Mass Medical Soc
In 1969, McCully made the clinical observation linking elevated plasma homocyst(e)ine
concentrations with vascular disease. He reported autopsy evidence of extensive arterial …
concentrations with vascular disease. He reported autopsy evidence of extensive arterial …
[BOOK][B] Harrison's principles of internal medicine, 19e
…, A Fauci, S Hauser, D Longo, J Jameson, J Loscalzo - 2015 - academia.edu
About 7 miles north east of this Institute there is a forested area called Zika. This area of
forest consists of a narrow, dense belt of high but broken canopy growth with clumps of large …
forest consists of a narrow, dense belt of high but broken canopy growth with clumps of large …
Biochemistry of nitric oxide and its redox-activated forms
Nitric oxide (NO ⋅ ), a potentially toxic molecule, has been implicated in a wide range of
biological functions. Details of its biochemistry, however, remain poorly understood. The …
biological functions. Details of its biochemistry, however, remain poorly understood. The …
Endothelial cells in physiology and in the pathophysiology of vascular disorders
…, ES Pollak, CA Buck, J Loscalzo… - Blood, The Journal …, 1998 - ashpublications.org
PART I THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane
that lines the circulatory system with its primary essential function being the maintenance of …
that lines the circulatory system with its primary essential function being the maintenance of …
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
…, D Singel, CR Valeri, J Loscalzo - Proceedings of the …, 1992 - National Acad Sciences
We have recently shown that nitric oxide or authentic endothelium-derived relaxing factor
generated in a biologic system reacts in the presence of specific protein thiols to form S-…
generated in a biologic system reacts in the presence of specific protein thiols to form S-…
S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.
Endothelium-derived relaxing factor (EDRF) activity has been attributed to the highly labile
nitric oxide radical (NO). In view of the fact that the plasma and cellular milieux contain …
nitric oxide radical (NO). In view of the fact that the plasma and cellular milieux contain …
Pulmonary arterial hypertension
HW Farber, J Loscalzo - New England Journal of Medicine, 2004 - Mass Medical Soc
This review of the mechanism of pulmonary hypertension is focused on pulmonary arterial
hypertension, a disorder that can be idiopathic or can occur in association with other disorders…
hypertension, a disorder that can be idiopathic or can occur in association with other disorders…
Uncovering disease-disease relationships through the incomplete interactome
INTRODUCTION A disease is rarely a straightforward consequence of an abnormality in a
single gene, but rather reflects the interplay of multiple molecular processes. The …
single gene, but rather reflects the interplay of multiple molecular processes. The …