The WHIM syndrome is a rare immunodeficiency disorder characterized by warts,
hypogammaglobulinemia, infections, and myelokathexis. Dominant heterozygous mutations of the …

Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of intensive
research because of its crucial role in the pathogenesis of different diseases across many …

Objectives The impact of inflammatory rheumatic diseases on COVID-19 severity is poorly
known. Here, we compare the outcomes of a cohort of patients with rheumatic diseases with a …

Stromal-cell derived factor or SDF-1 is a CXC chemokine constitutively expressed by
stromal bone marrow cell cultures that binds to the G-protein-coupled receptor CXCR4. SDF-1/…

Rheumatoid arthritis ( RA ) is a chronic inflammatory disease whose pathogenesis and severity
correlates with the presence of macrophage‐derived pro‐inflammatory cytokines within …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
in joints, associated with synovial hyperplasia and with bone and cartilage destruction. …

CXCL12 (stromal cell-derived factor-1) is a potent CXC chemokine that is constitutively
expressed by stromal resident cells. Although it is considered a homeostatic rather than an …

Background The susceptibility of patients with rheumatic diseases and the risks or benefits
of immunosuppressive therapies for COVID-19 are unknown. Methods We performed a …

Macrophages contribute to HIV-1 pathogenesis by forming a viral reservoir and mediating
neurological disorders. Cell-free HIV-1 infection of macrophages is inefficient, in part due to …

Objectives ABP 501 is a Food and Drug Administration-approved biosimilar to adalimumab;
structural, functional and pharmacokinetic evaluations have shown that the two are highly …