Interleukin-10 (IL-10) is produced at a high level by B lymphocytes and monocytes of patients
with systemic lupus erythematosus (SLE). In the present work, we analyzed whether this …

Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that
affects 0.05% of the Western population, predominantly women 1, 2, 3, 4. A number of …

Objective To evaluate the safety and clinical efficacy of administering an anti–interleukin‐10
(anti–IL‐10) monoclonal antibody (mAb) to systemic lupus erythematosus (SLE) patients …

CD4 + T cells that constitutively express CD25 exhibit powerful suppressive properties. Such
cells have been denominated regulatory T cells (T R ). Alterations in T R cells are known to …

We studied the production of and response to interleukin-2 (IL-2) by peripheral blood T
lymphocytes from 19 systemic lupus erythematosus (SLE) patients who received no treatment at …

Objective. Interleukin-10 (IL-10) is a potent stim-ulator of B lymphocytes in vitro. In vivo
dysregulation of IL-10 gene expression was therefore analyzed in patients with rheumatoid …

Cytotoxic T-Lymphocye Antigen 4 (CTLA-4) or CD152 is an inhibitory molecule that plays a
critical role in maintenance of tolerance to self-antigens. CTLA-4 is structurally as well as …

Diabetes mellitus has been linked to disorders of bones and joints, including neuroarthropathy,
limited joint mobility, and hyperostosis. Some of the relations have known pathogenic …

Objective As part of a larger, worldwide study of the ethnogeography of myositis, we evaluated
the clinical, serologic, and immunogenetic features of Mestizo (Mexican and Guatemalan) …

OBJECTIVE: To perform a systematic analysis and case-control study of our patients with
systemic lupus erythematosus (SLE) to determine the prevalence of acute pancreatitis (AP). …