Background Tumor necrosis factor (TNF) has a pathogenic role in juvenile rheumatoid
arthritis. We evaluated the efficacy and safety of adalimumab, a fully human monoclonal anti-TNF …

OBJECTIVE: To demonstrate the safety and efficacy of adalimumab for the treatment of
active psoriatic arthritis (PsA) in patients with an inadequate response to disease modifying …

Objective: To evaluate the effects of adalimumab on patient-reported outcomes of joint-related
and skin-related functional impairment, health-related quality of life, fatigue and pain in …

An efficient 11-step synthesis of the antisecretory prostaglandin enisoproststarting with (Z, Z)-l,
5-cyclooctadiene has been developed. The key steps in thesynthesis are a selective …

The utility of-alkoxy organostannanes as precursors to-alkoxy organolithiums has been
demonstrated by several groups. 1 Recently Macdonald, McGarvey, and co-workers published a …

The potent glucosidase inhibitor 1-deoxynojirimycin was synthesized from L-sorbose using
a short synthesis and only one protecting group. The last step, which constituted the removal …

Chiral amidocuprates, formed from CuI, n-butyl or methyl lithium and (S)-N-methyl-1-phenyl-2-(1-piperidinyl)ethanamine,
(S)-MAPP, react enantioselectively with 5, 6, 7 and 8-…

… De Jong, Adam Golebiowski, John R. Medich, Thomas D. Penning, Chrisantha H.
Senanayake, Darryl H. … JR Medich. K. Kunnen. …

The recent attention directed at the synthesis of compounds for the treatment of viral
infections has resulted in a large number of nucleoside analogues displaying antiviral activity. …

A hydroxymethyl anion equivalent: tributyl [(methoxymethoxy) methyl] stannane
intermediate:(tributylstannyl) methanol reactant: Boron trifluoride etherate (13.0 mL, 0.106 …