User profiles for John B. Harley

John B Harley

- Verified email at va.gov - Cited by 54649

John B Harley

- Verified email at cchmc.org - Cited by 3864

[HTML][HTML] Development of autoantibodies before the clinical onset of systemic lupus erythematosus

…, GJ Dennis, JA James, JB Harley - … England Journal of …, 2003 - Mass Medical Soc
Background Although much is known about the natural history of systemic lupus erythematosus
(SLE), the development of SLE autoantibodies before the diagnosis of the disease has …

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

…, JB Harley… - Nature …, 2008 - nature.com
Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with
complex etiology but strong clustering in families (λ S = ∼30). We performed a genome-wide …

The idiopathic hypereosinophilic syndrome: clinical, pathophysiologic, and therapeutic considerations

AS Fauci, JB HARLEY, WC ROBERTS… - Annals of internal …, 1982 - acpjournals.org
The idiopathic hypereosinophilic syndrome (HES) represents a heterogeneous group of
disorders with the common features of prolonged eosinophilia of an undetectable cause and …

A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans

…, R Jonsson, UB Gyllensten, JB Harley… - Nature …, 2002 - nature.com
Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that
affects 0.05% of the Western population, predominantly women 1, 2, 3, 4. A number of …

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

…, L Carreño, AH Sawalha, JB Harley… - Genome …, 2010 - genome.cshlp.org
Monozygotic (MZ) twins are partially concordant for most complex diseases, including
autoimmune disorders. Whereas phenotypic concordance can be used to study heritability, …

An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus.

…, E Taylor-Albert, TJ Lehman, JB Harley - The Journal of …, 1997 - Am Soc Clin Investig
An unknown environmental agent has been suspected to induce systemic lupus erythematosus
(lupus) in man. Prompted by our recent immunochemical findings, we sought evidence …

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome

…, BM Segal, RH Scofield, CG Montgomery, JB Harley… - Nature …, 2013 - nature.com
Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report …

Systemic lupus erythematosus in adults is associated with previous Epstein‐Barr virus exposure

…, GR Bruner, AL Sestak, JB Harley - … : Official Journal of …, 2001 - Wiley Online Library
Objective The possible molecular mimicry of the Epstein‐Barr virus (EBV) peptide PPPGRRP
by the peptide PPPGMRPP from Sm B′/B of the human spliceosome is consistent with the …

Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry

…, LD Heinlen, GJ Dennis, J Roebuck, JB Harley… - Nature medicine, 2005 - nature.com
The origins of autoimmunity in systemic lupus erythematosus (SLE) are thought to involve
both genetic and environmental factors. To identify environmental agents that could potentially …

Klinefelter's syndrome (47, XXY) in male systemic lupus erythematosus patients: support for the notion of a gene‐dose effect from the X chromosome

…, B Harris, S Li, JA Kelly, JB Harley - … : Official Journal of …, 2008 - Wiley Online Library
Objective Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that
predominantly affects women. Despite isolated reports of patients with coexisting Klinefelter's …