[HTML][HTML] Development of autoantibodies before the clinical onset of systemic lupus erythematosus
Background Although much is known about the natural history of systemic lupus erythematosus
(SLE), the development of SLE autoantibodies before the diagnosis of the disease has …
(SLE), the development of SLE autoantibodies before the diagnosis of the disease has …
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
…, JB Harley… - Nature …, 2008 - nature.com
Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with
complex etiology but strong clustering in families (λ S = ∼30). We performed a genome-wide …
complex etiology but strong clustering in families (λ S = ∼30). We performed a genome-wide …
The idiopathic hypereosinophilic syndrome: clinical, pathophysiologic, and therapeutic considerations
The idiopathic hypereosinophilic syndrome (HES) represents a heterogeneous group of
disorders with the common features of prolonged eosinophilia of an undetectable cause and …
disorders with the common features of prolonged eosinophilia of an undetectable cause and …
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
…, R Jonsson, UB Gyllensten, JB Harley… - Nature …, 2002 - nature.com
Systemic lupus erythematosus (SLE, OMIM 152700) is a complex autoimmune disease that
affects 0.05% of the Western population, predominantly women 1, 2, 3, 4. A number of …
affects 0.05% of the Western population, predominantly women 1, 2, 3, 4. A number of …
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
…, L Carreño, AH Sawalha, JB Harley… - Genome …, 2010 - genome.cshlp.org
Monozygotic (MZ) twins are partially concordant for most complex diseases, including
autoimmune disorders. Whereas phenotypic concordance can be used to study heritability, …
autoimmune disorders. Whereas phenotypic concordance can be used to study heritability, …
An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus.
An unknown environmental agent has been suspected to induce systemic lupus erythematosus
(lupus) in man. Prompted by our recent immunochemical findings, we sought evidence …
(lupus) in man. Prompted by our recent immunochemical findings, we sought evidence …
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome
Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report …
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report …
Systemic lupus erythematosus in adults is associated with previous Epstein‐Barr virus exposure
…, GR Bruner, AL Sestak, JB Harley - … : Official Journal of …, 2001 - Wiley Online Library
Objective The possible molecular mimicry of the Epstein‐Barr virus (EBV) peptide PPPGRRP
by the peptide PPPGMRPP from Sm B′/B of the human spliceosome is consistent with the …
by the peptide PPPGMRPP from Sm B′/B of the human spliceosome is consistent with the …
Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry
…, LD Heinlen, GJ Dennis, J Roebuck, JB Harley… - Nature medicine, 2005 - nature.com
The origins of autoimmunity in systemic lupus erythematosus (SLE) are thought to involve
both genetic and environmental factors. To identify environmental agents that could potentially …
both genetic and environmental factors. To identify environmental agents that could potentially …
Klinefelter's syndrome (47, XXY) in male systemic lupus erythematosus patients: support for the notion of a gene‐dose effect from the X chromosome
…, B Harris, S Li, JA Kelly, JB Harley - … : Official Journal of …, 2008 - Wiley Online Library
Objective Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that
predominantly affects women. Despite isolated reports of patients with coexisting Klinefelter's …
predominantly affects women. Despite isolated reports of patients with coexisting Klinefelter's …