Safety and efficacy of long‐term intraarticular steroid injections in osteoarthritis of the knee: A randomized, double‐blind, placebo‐controlled trial

…, B Haraoui, J MartelPelletier… - Arthritis & …, 2003 - Wiley Online Library
Objective To evaluate the safety and efficacy of long‐term intraarticular (IA) steroid injections
for knee pain related to osteoarthritis (OA). Methods In a randomized, double‐blind trial, 68 …

IL-17 stimulates the production and expression of proinflammatory cytokines, IL-β and TNF-α, by human macrophages

…, JA Di Battista, J Martel-Pelletier… - The Journal of …, 1998 - journals.aai.org
IL-17 is a newly described, T cell-derived cytokine with ill-defined physiologic properties. As
such, we examined the release of proinflammatory mediators by human macrophages in …

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

M Kapoor, J Martel-Pelletier, D Lajeunesse… - Nature Reviews …, 2011 - nature.com
Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling
and inflammation of the synovial membrane, although the etiology and pathogenesis …

[PDF][PDF] Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets

JP Pelletier, J MartelPelletier… - Arthritis & Rheumatism …, 2001 - stem-art.com
Osteoarthritis (OA) is a well-known disease that is part of the aging process and also one of
the most common diseases among mammals. Although this musculoskeletal disorder has …

The role of cytokines in osteoarthritis pathophysiology

JC Fernandes, J MartelPelletier, JP Pelletier - Biorheology, 2002 - content.iospress.com
Morphological changes observed in OA include cartilage erosion as well as a variable degree
of synovial inflammation. Current research attributes these changes to a complex network …

[HTML][HTML] An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for …

…, JA Kanis, TK Kvien, J Martel-Pelletier… - Seminars in arthritis and …, 2014 - Elsevier
Objectives Existing practice guidelines for osteoarthritis (OA) analyze the evidence behind
each proposed treatment but do not prioritize the interventions in a given sequence. The …

Cartilage in normal and osteoarthritis conditions

J Martel-Pelletier, C Boileau, JP Pelletier… - Best practice & research …, 2008 - Elsevier
The preservation of articular cartilage depends on keeping the cartilage architecture intact.
Cartilage strength and function depend on both the properties of the tissue and on their …

Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage.

DD Dean, J Martel-Pelletier, JP Pelletier… - The Journal of …, 1989 - Am Soc Clin Investig
Martel-Pelletier. 1985. Neutral proteoglycan degrading protease activity in the early …
Martel-Pelletier. Cartilage degradation by neutral proteoglycanases in experimental osteoarthritis: …

[HTML][HTML] An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of …

…, G Herrero-Beaumont, J Martel-Pelletier… - Seminars in arthritis and …, 2019 - Elsevier
Objectives The European Society for Clinical and Economic Aspects of Osteoporosis,
Osteoarthritis and Musculoskeletal Diseases (ESCEO) sought to revisit the 2014 algorithm …

The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis.

…, G Tardif, JM Cloutier, J Martel-Pelletier - The Journal of …, 1996 - Am Soc Clin Investig
Recently, a new human collagenase, collagenase-3 has been identified. Since collagen
changes are of particular importance in cartilage degeneration, we investigated if collagenase-…