Objectives. The objective of this study was to estimate the societal costs of prescription opioid
abuse, dependence, and misuse in the United States. Methods. Costs were grouped into …

Objectives: To evaluate potential for and incidence of aberrant drug-related behaviors among
patients with chronic, moderate-to-severe pain in a primary care setting and to determine …

Objectives. Remoxy ® is a water-insoluble, highly viscous oral formulation of oxycodone
extended release (ER) currently in development. The primary objective was to determine the …

Objectives The primary objective of this long-term follow-up (LTFU) trial was to evaluate the
long-term safety and tolerability of brivaracetam (BRV). The secondary objective was to …

This long-term open-label extension (OLE) trial was conducted to evaluate the long-term
safety and tolerability of brivaracetam (BRV) at individualized doses in patients with epilepsy …

Objective. Prior studies investigating the efficacy of oral treprostinil to treat digital ulcers (DU)
in systemic sclerosis (SSc)-associated Raynaud phenomenon have yielded conflicting …

Objective Despite introduction of several antiseizure medications over the past two decades,
treatment options for childhood absence epilepsy (CAE) and juvenile absence epilepsy (…

Objective Midazolam nasal spray (MDZ‐NS) is indicated for acute treatment of intermittent,
stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) …

Background In recent years, the population of patients with pulmonary arterial hypertension (PAH)
has changed dramatically, including more advanced age at diagnosis. We …

Intra- and interpatient variability in opioid response usually necessitates opioid therapy titration
to optimally balance analgesia and side effects, whether initiating therapy or converting …