Ventral tegmental area (VTA) dopamine neurons in the brain’s reward circuit have a crucial
role in mediating stress responses 1 , 2 , 3 , 4 , including determining susceptibility versus …

Objective: To develop an evidence-based guideline for the pharmacologic and nonpharmacologic
treatment of psoriatic arthritis (PsA), as a collaboration between the American College …

Typical therapies try to reverse pathogenic mechanisms. Here, we describe treatment
effects achieved by enhancing depression-causing mechanisms in ventral tegmental area (VTA) …

The reward generated by social interactions is critical for promoting prosocial behaviors.
Here we present evidence that oxytocin (OXT) release in the ventral tegmental area (VTA), a …

We previously reported that the activity of mesolimbic dopamine neurons of the ventral
tegmental area (VTA) is a key determinant of behavioral susceptibility vs resilience to chronic …

Objective To develop new composite disease activity indices for psoriatic arthritis (PsA).
Methods Data from routine clinic visits at multiple centres were collected in a systematic manner. …

Making decisions informed by the best-available science is an objective for many organisations
managing the environment or natural resources. Yet, available science is still not widely …

Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet
unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone and …

Mechanisms controlling release of brain-derived neurotrophic factor (BDNF) in the mesolimbic
dopamine reward pathway remain unknown. We report that phasic optogenetic activation …

A major justification of environmental management research is that it helps practitioners, yet
previous studies show it is rarely used to inform their decisions. We tested whether …