Introduction Most childhood-onset SLE patients (cSLE) develop lupus nephritis (cLN), but
only a small proportion achieve complete response to current therapies. The prognosis of …

Objective To assess the safety, tolerability, pharmacokinetics, and efficacy of rituximab (RTX)
in pediatric patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis …

Objectives: To develop a Pediatric Glucocorticoid Toxicity Index (pGTI), a standardized,
weighted clinical outcome assessment that measures change in glucocorticoid (GC) toxicity over …

Background To reduce treatment variability and facilitate comparative effectiveness studies,
the Childhood Arthritis and Rheumatology Research Alliance (CARRA) published …

Objective We compared clinical characteristics and renal response in patients with
childhood‐onset proliferative lupus nephritis (LN) treated with the EuroLupus versus National …

Background Acute kidney injury (AKI) is common in lupus nephritis (LN) and a risk factor for
development of chronic kidney disease. In adults with LN, AKI severity correlates with the …

A 14-year-old patient presents with hematuria and proteinuria. Clinical evaluation reveals a
positive anti-nuclear antibody titer, positive anti-double stranded DNA antibody and …

Objectives To develop a simultaneous population pharmacokinetic model of cyclophosphamide
(CY) and 4-hydroxycyclophosphamide (4-OH) in patients with glomerulonephritis. …

Diffuse large B cell lymphoma (DLBCL) is an aggressive malignancy that accounts for nearly
40% of all lymphoid tumors. This heterogeneous disease can be divided into germinal …

A high proportion of synovial sarcomas contain a chromosome translocation t(X;18)(p11.2;q11.2).
We have previously used somatic cell hybrids derived from an established cell line, …