[HTML][HTML] Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells
…, M Van Landeghen, JH Buckner… - The Journal of …, 2003 - Am Soc Clin Investig
CD4 + CD25 + regulatory T (T R ) cells have been described in both humans and mice. In
mice, T R are thymically derived, and lack of T R leads to organ-specific autoimmunity. …
mice, T R are thymically derived, and lack of T R leads to organ-specific autoimmunity. …
Type 1 diabetes immunotherapy using polyclonal regulatory T cells
JA Bluestone, JH Buckner, M Fitch… - Science translational …, 2015 - science.org
Type 1 diabetes (T1D) is an autoimmune disease that occurs in genetically susceptible
individuals. Regulatory T cells (T regs ) have been shown to be defective in the autoimmune …
individuals. Regulatory T cells (T regs ) have been shown to be defective in the autoimmune …
Complement receptor 2/CD21− human naive B cells contain mostly autoreactive unresponsive clones
…, J Samuels, J Berman, JH Buckner… - Blood, The Journal …, 2010 - ashpublications.org
Complement receptor 2–negative (CR2/CD21 − ) B cells have been found enriched in patients
with autoimmune diseases and in common variable immunodeficiency (CVID) patients …
with autoimmune diseases and in common variable immunodeficiency (CVID) patients …
Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes
…, C Greenbaum, P Concannon, JH Buckner - The Journal of …, 2007 - journals.aai.org
A variant of the PTPN22 gene, 1858C/T, is associated with an increased risk for the
development of a wide array of autoimmune disorders. It is known that the protein tyrosine …
development of a wide array of autoimmune disorders. It is known that the protein tyrosine …
Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum
…, KD Deane, EA James, JH Buckner… - Science translational …, 2022 - science.org
The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for
mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity that …
mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity that …
The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells
…, C Pihoker, C Greenbaum, JH Buckner - The Journal of …, 2008 - journals.aai.org
Defects in immune regulation have been implicated in the pathogenesis of diabetes in mouse
and in man. In vitro assays using autologous regulatory (Treg) and responder effector (Teff…
and in man. In vitro assays using autologous regulatory (Treg) and responder effector (Teff…
Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects
…, C Pihoker, S Sanda, C Greenbaum, JH Buckner - …, 2010 - Am Diabetes Assoc
OBJECTIVE In humans, multiple genes in the interleukin (IL)-2/IL-2 receptor (IL-2R) pathway
are associated with type 1 diabetes. However, no link between IL-2 responsiveness and …
are associated with type 1 diabetes. However, no link between IL-2 responsiveness and …
CD4+ FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game
SA Long, JH Buckner - The journal of immunology, 2011 - journals.aai.org
Regulatory T cells (Treg) play a dominant role in suppression of autoimmune pathology, as
rescue of Treg number and/or function in model systems can both prevent and reverse …
rescue of Treg number and/or function in model systems can both prevent and reverse …
[HTML][HTML] The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans
…, C Abraham, R Motaghedi, JH Buckner… - The Journal of …, 2011 - Am Soc Clin Investig
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphisms are
associated with many autoimmune diseases. The major risk allele encodes an R620W amino …
associated with many autoimmune diseases. The major risk allele encodes an R620W amino …
Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function
…, KD Boyle, SA Adah, JA Bluestone, JH Buckner… - Diabetes, 2012 - Am Diabetes Assoc
Rapamycin/interleukin-2 (IL-2) combination treatment of NOD mice effectively treats
autoimmune diabetes. We performed a phase 1 clinical trial to test the safety and immunologic …
autoimmune diabetes. We performed a phase 1 clinical trial to test the safety and immunologic …