Objective: To carry out a multicenter, prospective, randomized trial of human growth hormone
(GH), alone or in combination with oxandrolone (OX), in patients with Turner's syndrome (…

Context: Children with severe IGF-I deficiency due to congenital or acquired defects in GH
action have short stature that cannot be remedied by GH treatment. Objectives: The objective …

Context: Although GH has been used to treat short stature in GH deficiency (GHD) and other
conditions for more than 40 yr, criteria for satisfactorily defining targets for GH …

Many randomized studies in small patient populations and studies in early research (such as
Phase I and Phase II trials) have small to moderate numbers of patients. In such studies the …

Clinical trials of recombinant human GH therapy in Turner syndrome that began more than
a decade ago show that GH accelerates the linear growth rate. Several studies indicate that …

Aim: A recent secular trend towards earlier thelarche has been suggested. The aim of this
study is to examine normative ages of thelarche and menarche in contemporary US females. …

Context: Small clinical trials of GH treatment of idiopathic short stature (ISS) show variable
efficacy. Objective: The study was an analysis of a large GH registry for efficacy and safety of …

… FRANE … Requests for reprints should be sent to James W. Frane, Department of
Biomathematics, University of California, Los Angeles, California 90024. …

Demographic, diagnostic, and baseline clinical data were collected for a large cohort (N=2331)
of children who started treatment with biosynthetic human growth hormone (GH) …

Objective To investigate the impact of tocilizumab treatment on growth and growth‐related
laboratory parameters in patients with systemic juvenile idiopathic arthritis (JIA) enrolled in a …