Interleukin-lβ converting enzyme (ICE) processes an inactive precursor to the proinflammatory
cytokine, interleukin-lβ, and may regulate programmed cell death in neuronal cells. The …

The X-ray structure of the ternary complex of a calcineurin A fragment, calcineurin B,
FKBP12, and the immunosuppreseant drug FK506 (also known as tacrolimus) has been …

Background: Hepatitis C virus (HCV) represents a major health concern as it is responsible
for a significant number of hepatitis cases worldwide. Much research has focused on the …

CpG islands (CGIs) are prominent in the mammalian genome owing to their GC-rich base
composition and high density of CpG dinucleotides 1 , 2 . Most human gene promoters are …

… The Microlichens is the second volume of John W. Thomson's fundamental reference work
on the lichens of the American Arctic. Thomson, the world's foremost lichenologist of the arctic …

The pH of the colonic lumen varies with anatomical site and microbial fermentation of dietary
residue. We have investigated the impact of mildly acidic pH, which occurs in the proximal …

Between 1983 and 1987 the Radiation Therapy Oncology Group conducted a prospective
phase II study to evaluate survival in primary non-Hodgkin's lymphoma of the brain treated …

Iterative compiler optimization has been shown to outperform static approaches. This, however,
is at the cost of large numbers of evaluations of the program. This paper develops a new …

THE HE rapid exhaustion of the large first edition (1889) of this book, and of subsequent
reprints also, seems to show the need of a general survey of the essential phenomena of …

After liver injury, regeneration occurs through self-replication of hepatocytes. In severe liver
injury, hepatocyte proliferation is impaired—a feature of human chronic liver disease 1 , 2 . It …