Background Cognitive behaviour therapy (CBT) seems a promising treatment for chronic
fatigue syndrome (CFS), but the applicability of this treatment outside specialized settings has …

Objective To study the effect of folates on discontinuation of methotrexate (MTX) as single‐drug
antirheumatic treatment due to toxicity, to determine which type of adverse events are …

Purpose Fluoropyrimidines are frequently prescribed anticancer drugs. A polymorphism in
the fluoropyrimidine metabolizing enzyme dihydropyrimidine dehydrogenase (DPD; ie, DPYD…

OBJECTIVE: To assess the feasibility and validity of two instruments for the measurement of
health-related productivity loss at work. STUDY DESIGN AND SETTING: A cross-sectional …

Background In patients with prostate cancer who are deemed to be at intermediate or high
risk of having nodal metastases, invasive diagnostic pelvic lymph-node dissection (PLND) is …

BackgroundBorderline personality disorder (BPD) is a highly prevalent, chronic condition.
Because of its very problematic nature BPD is expected to be associated with substantial …

BackgroundSchema-focused therapy (SFT) and transference-focused psychotherapy (TFP)
for borderline personality disorder were recently compared in a randomised multicentre trial.…

PURPOSE: Particle therapy has potentially a better therapeutic ratio than photon therapy.
However, investment costs are much higher. This study provides an estimation and …

The impact of disease on the ability of a person to perform work should be part of an economic
evaluation when a societal viewpoint is used for the analysis. This impact is reflected by …

It is necessary to understand the full burden of illness of a disease before the value of
interventions can be assessed. Rheumatoid arthritis (RA) has an impact on a variety of …