Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling
and inflammation of the synovial membrane, although the etiology and pathogenesis …

IL-17 is a newly described, T cell-derived cytokine with ill-defined physiologic properties. As
such, we examined the release of proinflammatory mediators by human macrophages in …

… Address correspondence and reprint requests to Jean-Pierre Pelletier, MD, Unité de
recherche en arthrose, Centre Hospitalier de l’Université de Montréal, Hôpital Notre-Dame, 1560 …

Morphological changes observed in OA include cartilage erosion as well as a variable degree
of synovial inflammation. Current research attributes these changes to a complex network …

Objective To evaluate the safety and efficacy of long‐term intraarticular (IA) steroid injections
for knee pain related to osteoarthritis (OA). Methods In a randomized, double‐blind trial, 68 …

Objectives Existing practice guidelines for osteoarthritis (OA) analyze the evidence behind
each proposed treatment but do not prioritize the interventions in a given sequence. The …

The preservation of articular cartilage depends on keeping the cartilage architecture intact.
Cartilage strength and function depend on both the properties of the tissue and on their …

Background: The relation between knee meniscal structural damage and cartilage degradation
is plausible but not yet clearly proven. Objectives: To quantitate the cartilage volume …

Cartilage specimens from tibial plateaus, obtained from 13 osteoarthritic (OA) patients and
seven controls, were selected from three regions: zone A, center of fibrillated area; zone B, …

… Al-Daghri g , Gabriel Herrero-Beaumont h , Johanne Martel-Pelletier i , Jean-Pierre Pelletier
i , François Rannou j , René Rizzoli b k , Roland Roth l , Daniel Uebelhart m , Cyrus Cooper …