The study of microvascular function can be performed in humans using laser Doppler flowmetry
of the skin. This technology lends itself to a wide range of applications for studying the …

… Jean-Luc Cracowski is MD, PhD, professor of Clinical Pharmacology at Grenoble University,
France. He is in charge of the Clinical Pharmacology Unit at the INSERM Clinical Research …

Isoprostanes are a complex family of compounds produced from arachidonic acid via a free-radical-catalyzed
mechanism. They can be quantified as reliable markers of lipid …

Peripheral microvascular dysfunction has been described in many physiological and pathological
conditions. Owing to its accessibility, the cutaneous microcirculation provides a unique …

Objective. To measure the prevalence of different types of pulmonary hypertension (PH) and
to identify patients with systemic sclerosis (SSc) at highest risk in a multicenter European …

The passe sanitaire increased levels of vaccination, but to a lower extent among the most
vulnerable, and did not reduce vaccine hesitancy itself, showing the importance of outreach …

Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune
system and connective tissue. SSc stands out as a severely incapacitating and life-…

Methods| Disproportionality analyses are hypothesisgenerating methods that aim to detect
putative associations between drugs and adverse drug reactions. Such methods quantify the …

Isoprostanes are chemically stable lipid peroxidation products of arachidonic acid, the
quantification of which provides a novel approach to the assessment of oxidative stress in vivo. …

Introduction Recent controlled trials have assessed the efficacy of phospodiesterase-5 (PDE-5)
inhibitors in secondary Raynaud's phenomenon (RP). However, the conclusions are …