User profiles for JANNA SAARELA
Janna saija saarelaProfessor University of Oslo Verified email at helsinki.fi Cited by 11470 |
[HTML][HTML] Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia
…, A Parsons, J Knowles, J Saarela… - … England Journal of …, 2012 - Mass Medical Soc
Background T-cell large granular lymphocytic leukemia is a rare lymphoproliferative disorder
characterized by the expansion of clonal CD3+CD8+ cytotoxic T lymphocytes (CTLs) and …
characterized by the expansion of clonal CD3+CD8+ cytotoxic T lymphocytes (CTLs) and …
[HTML][HTML] Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox‐1 homeobox transcription factor
Lymphatic vessels are essential for fluid homeostasis, immune surveillance and fat adsorption,
and also serve as a major route for tumor metastasis in many types of cancer. We found …
and also serve as a major route for tumor metastasis in many types of cancer. We found …
Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis
Multiple sclerosis is a chronic, often disabling, disease of the central nervous system affecting
more than 1 in 1,000 people in most western countries. The inflammatory lesions typical of …
more than 1 in 1,000 people in most western countries. The inflammatory lesions typical of …
The Twin Spine Study: contributions to a changing view of disc degeneration
BACKGROUND CONTEXT: Disc degeneration was commonly viewed over much of the last
century as a result of aging and “wear and tear” from mechanical insults and injuries. Thus, …
century as a result of aging and “wear and tear” from mechanical insults and injuries. Thus, …
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)
…, A Soro-Paavonen, J Naukkarinen, J Saarela… - Nature …, 2004 - nature.com
Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total
cholesterol, triglycerides or both 1 , 2 , is observed in about 20% of individuals with premature …
cholesterol, triglycerides or both 1 , 2 , is observed in about 20% of individuals with premature …
A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis
Genetic susceptibility to multiple sclerosis is associated with genes of the major histocompatibility
complex (MHC), particularly HLA-DRB1 and HLA-DQB1 (ref. 1 ). Both locus and allelic …
complex (MHC), particularly HLA-DRB1 and HLA-DQB1 (ref. 1 ). Both locus and allelic …
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to
fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation 1 , 2 , …
fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation 1 , 2 , …
[HTML][HTML] Comparison of solution-based exome capture methods for next generation sequencing
…, H Joensuu, T Raivio, A Suomalainen, J Saarela - Genome biology, 2011 - Springer
Background Techniques enabling targeted re-sequencing of the protein coding sequences
of the human genome on next generation sequencing instruments are of great interest. We …
of the human genome on next generation sequencing instruments are of great interest. We …
Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3
…, R Uusitalo-Seppälä, J Saarela… - Blood, The Journal …, 2015 - ashpublications.org
The signal transducer and activator of transcription (STAT) family of transcription factors
orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and …
orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and …
[PDF][PDF] Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene
Genetic risk for multiple sclerosis (MS) is thought to involve both common and rare risk alleles.
Recent GWAS and subsequent meta-analysis have established the critical role of the HLA …
Recent GWAS and subsequent meta-analysis have established the critical role of the HLA …