User profiles for JANNA SAARELA

Janna saija saarela

Professor University of Oslo
Verified email at helsinki.fi
Cited by 11470

[HTML][HTML] Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia

…, A Parsons, J Knowles, J Saarela… - … England Journal of …, 2012 - Mass Medical Soc
Background T-cell large granular lymphocytic leukemia is a rare lymphoproliferative disorder
characterized by the expansion of clonal CD3+CD8+ cytotoxic T lymphocytes (CTLs) and …

[HTML][HTML] Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox‐1 homeobox transcription factor

TV Petrova, T Mäkinen, TP Mäkelä, J Saarela… - The EMBO …, 2002 - embopress.org
Lymphatic vessels are essential for fluid homeostasis, immune surveillance and fat adsorption,
and also serve as a major route for tumor metastasis in many types of cancer. We found …

Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis

…, M Khademi, A Oturai, LP Ryder, J Saarela… - Nature …, 2007 - nature.com
Multiple sclerosis is a chronic, often disabling, disease of the central nervous system affecting
more than 1 in 1,000 people in most western countries. The inflammatory lesions typical of …

The Twin Spine Study: contributions to a changing view of disc degeneration

…, J Kaprio, LE Gibbons, K Gill, H Manninen, J Saarela… - The Spine Journal, 2009 - Elsevier
BACKGROUND CONTEXT: Disc degeneration was commonly viewed over much of the last
century as a result of aging and “wear and tear” from mechanical insults and injuries. Thus, …

Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)

…, A Soro-Paavonen, J Naukkarinen, J Saarela… - Nature …, 2004 - nature.com
Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total
cholesterol, triglycerides or both 1 , 2 , is observed in about 20% of individuals with premature …

A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis

MR Lincoln, A Montpetit, MZ Cader, J Saarela… - Nature …, 2005 - nature.com
Genetic susceptibility to multiple sclerosis is associated with genes of the major histocompatibility
complex (MHC), particularly HLA-DRB1 and HLA-DQB1 (ref. 1 ). Both locus and allelic …

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis

…, M Sterneck, A Teufel, AL Mason, J Saarela… - Nature …, 2013 - nature.com
Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to
fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation 1 , 2 , …

[HTML][HTML] Comparison of solution-based exome capture methods for next generation sequencing

…, H Joensuu, T Raivio, A Suomalainen, J Saarela - Genome biology, 2011 - Springer
Background Techniques enabling targeted re-sequencing of the protein coding sequences
of the human genome on next generation sequencing instruments are of great interest. We …

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3

…, R Uusitalo-Seppälä, J Saarela… - Blood, The Journal …, 2015 - ashpublications.org
The signal transducer and activator of transcription (STAT) family of transcription factors
orchestrate hematopoietic cell differentiation. Recently, mutations in STAT1, STAT5B, and …

[PDF][PDF] Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene

…, DA Hafler, MJ Daly, A Palotie, J Saarela… - The American Journal of …, 2010 - cell.com
Genetic risk for multiple sclerosis (MS) is thought to involve both common and rare risk alleles.
Recent GWAS and subsequent meta-analysis have established the critical role of the HLA …