Objective The 1980 American College of Rheumatology (ACR) classification criteria for
systemic sclerosis (SSc) lack sensitivity for early SSc and limited cutaneous SSc. The present …

Background A phase 2 trial of tocilizumab showed preliminary evidence of efficacy in systemic
sclerosis. We assessed skin fibrosis and systemic sclerosis-associated interstitial lung …

The aim was to update the 2009 European League against Rheumatism (EULAR)
recommendations for the treatment of systemic sclerosis (SSc), with attention to new therapeutic …

… : Drs van Laar and Farge had full access to all of the data in the study and take responsibility
for the integrity of the data and the accuracy of the data analysis. Drs van Laar … Dr van Laar …

Background Ankylosing spondylitis is a chronic immune-mediated inflammatory disease
characterised by spinal inflammation, progressive spinal rigidity, and peripheral arthritis. …

To update the European League Against Rheumatism (EULAR) recommendations for vaccination
in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) published …

Background Systemic sclerosis is a rare disabling autoimmune disease with few treatment
options. The efficacy and safety of tocilizumab, an interleukin 6 receptor-α inhibitor, was …

Objective Regulatory T cells play an important role in the prevention of autoimmunity and have
been shown to be effective in the treatment of experimental colitis, a T cell–mediated and …

PURPOSE: Studies on mortality associated with systemic sclerosis have been limited by
small sample sizes. We aimed to obtain large-scale evidence on survival outcomes and …

Osteoporosis is characterised by low bone mass and structural deterioration of bone tissue,
resulting in increased fragility and susceptibility to fracture. Osteoporotic fractures are a …