The immune system is a fascinating world of cells, soluble factors, interacting cells, and tissues,
all of which are interconnected. The highly complex nature of the immune system makes …

Using variants from the 1000 Genomes Project pilot European CEU dataset and data from
additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously …

Objective The STAT4 gene encodes a transcription factor involved in the signaling
pathways of several cytokines, including interleukin‐12 (IL‐12), the type I interferons, and IL‐23. …

Background and aim Several studies have highlighted the association of the 12q13.3–12q14.1
region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple sclerosis (…

The macrophage inhibitory factor (MIF) is a cytokine that has been implicated in several
inflammatory and autoimmune diseases, including rheumatoid arthritis, systemic lupus, …

Multiple sclerosis (MS) shares some risk genes with other disorders hallmarked by an
autoimmune pathogenesis, most notably IL2RA and CLEC16A. We analyzed 10 single-nucleotide …

Background Human endogenous retroviruses (HERVs) are genomic sequences that
resulted from ancestral germ-line infections by exogenous retroviruses and therefore are …

Several variants in strong linkage disequilibrium (LD) at the SP140 locus have been associated
with multiple sclerosis (MS), Crohn's disease (CD) and chronic lymphocytic leukemia (…

Objective Semaphorin 3B (Sema3B) decreases the migratory and invasive capacities of
fibroblast‐like synoviocytes (FLS) in rheumatoid arthritis (RA) and suppresses expression of …

Objective: Genome-wide studies have identified the chromosomal region 16p13 in the
susceptibility to type 1 diabetes (T1D) and multiple sclerosis (MS). This region includes the …