The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
J Sellam, F Berenbaum - Nature Reviews Rheumatology, 2010 - nature.com
Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by cartilage
breakdown and by synovial inflammation that is directly linked to clinical symptoms such …
breakdown and by synovial inflammation that is directly linked to clinical symptoms such …
The role of metabolism in the pathogenesis of osteoarthritis
…, MP Rayman, O Gualillo, J Sellam… - Nature Reviews …, 2017 - nature.com
Metabolism is important for cartilage and synovial joint function. Under adverse microenvironmental
conditions, mammalian cells undergo a switch in cell metabolism from a resting …
conditions, mammalian cells undergo a switch in cell metabolism from a resting …
[HTML][HTML] Economic impact of lower-limb osteoarthritis worldwide: a systematic review of cost-of-illness studies
JH Salmon, AC Rat, J Sellam, M Michel… - Osteoarthritis and …, 2016 - Elsevier
Objective An overview of the economic consequences – overall costs as well as cost
breakdown (direct and indirect) – of hip and knee osteoarthritis (OA) worldwide. Methods A …
breakdown (direct and indirect) – of hip and knee osteoarthritis (OA) worldwide. Methods A …
Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial
… Jérémie Sellam8, … SA, BB, LB, FB, BF, JC, OC, CC, CF, AM, ER, DS, PS, JS and J-ES were
clinical investigators of the study. CR was an assistant clinical investigator and supervised the …
clinical investigators of the study. CR was an assistant clinical investigator and supervised the …
[HTML][HTML] Increased levels of circulating microparticles in primary Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease …
J Sellam, V Proulle, A Jüngel, M Ittah… - Arthritis research & …, 2009 - Springer
Introduction Cell stimulation leads to the shedding of phosphatidylserine (PS)-rich microparticles
(MPs). Because autoimmune diseases (AIDs) are characterized by cell activation, we …
(MPs). Because autoimmune diseases (AIDs) are characterized by cell activation, we …
[HTML][HTML] B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary …
…, F Lavie, T Lazure, N Ba, J Sellam… - Arthritis research & …, 2006 - Springer
… Positive staining with cytokeratin 7 (i) and the absence of staining with cytokeratin 20 (j)
indicate the ductal epithelial origin of HSG cell lines. Negative staining with myeloperoxydase (…
indicate the ductal epithelial origin of HSG cell lines. Negative staining with myeloperoxydase (…
Is osteoarthritis a metabolic disease?
J Sellam, F Berenbaum - Joint bone spine, 2013 - Elsevier
Obesity, together with aging and injury, is among the main risk factors for osteoarthritis.
Obesity-related osteoarthritis can affect not only the weight-bearing joints, but also the hands, …
Obesity-related osteoarthritis can affect not only the weight-bearing joints, but also the hands, …
Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis
K Louati, C Vidal, F Berenbaum, J Sellam - RMD open, 2015 - rmdopen.bmj.com
Objectives To investigate the prevalence of osteoarthritis (OA) in patients with diabetes mellitus
(DM) and prevalence of DM in patients with OA and whether OA and DM are associated. …
(DM) and prevalence of DM in patients with OA and whether OA and DM are associated. …
Non–TNF-targeted biologic vs a second anti-TNF drug to treat rheumatoid arthritis in patients with insufficient response to a first anti-TNF drug: a randomized clinical …
…, F Lioté, H Marotte, C Bonnet, C Marcelli, J Sellam… - Jama, 2016 - jamanetwork.com
Importance One-third of patients with rheumatoid arthritis show inadequate response to tumor
necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists. …
necrosis factor α (TNF-α) inhibitors; little guidance on choosing the next treatment exists. …
[HTML][HTML] Metabolic stress-induced joint inflammation and osteoarthritis
A Courties, O Gualillo, F Berenbaum, J Sellam - Osteoarthritis and cartilage, 2015 - Elsevier
Osteoarthritis (OA) is a heterogeneous disorder with several risk factors. Among them,
obesity has a major impact on both loading and non-loading joints. Mechanical overload and …
obesity has a major impact on both loading and non-loading joints. Mechanical overload and …