This review provides information on the most recent findings concerning presence, origin,
and role of kynurenic acid (KYNA), a tryptophan metabolite, in the digestive system. KYNA is …

Kynurenic acid (KYNA), a metabolite of tryptophan, is an endogenous substance produced
intracellularly by various human cells. In addition, KYNA can be synthesized by the gut …

Kynurenic acid is an antagonist of glutamate and alpha-7 nicotinic acetylcholine receptors
and an agonist of the g-protein-coupled receptor GPR35, which is predominantly expressed …

The role of N- methyl- d -aspartate (NMDA) receptors in memory processes was examined
using a Y-shaped maze and a step-through passive avoidance task in mice. In the Y-maze, …

Zingiber officinale is one of the most frequently used medicinal herbs in Asia. Using rodent
seizure models, it was previously shown that Zingiber officinale hydroethanolic extract exerts …

A meta-analysis of publicly available transcriptomic datasets was performed to identify metabolic
pathways profoundly implicated in the progression and treatment of inflammatory bowel …

Retigabine represents an antiepileptic drug possessing a completely different mechanism
of action when compared to the existing classical and newer antiepileptic drugs. In the …

Kynurenic acid (KYNA) is a metabolite of tryptophan exerting a number of positive actions in
rodents, including anti-inflammatory and antioxidative activity. In this study, an analysis of …

Polytherapy, based on the rational combining of antiepileptic drugs (AEDs), is required for
patients with drug-resistant epilepsy. In such cases, the combinations of AEDs usually offer a …

Acute liver failure (ALF) is a life-threatening disorder of liver function. Kynurenic acid (KYNA),
a tryptophan metabolite formed along the kynurenine metabolic pathway, possesses anti-…