In healthy lung, Matrix Metalloproteinases (MMPs) and their physiological inhibitors, tissue
inhibitors of matrix metalloproteinases (TIMPs), are produced in the respiratory tract by a …

A disintegrin and metalloproteinases (ADAMs) are a recently discovered family of proteins
that share the metalloproteinase domain with matrix metalloproteinases (MMPs). Among this …

The success of implantation depends on a receptive endometrium, a normal blastocyst and
synchronized cross-talk at the maternal–fetal interface. The progression of pregnancy then …

Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF
receptor-2 (VEGFR-2). The role of its homolog, placental growth factor (PlGF), remains unknown. …

We have isolated a large noncollagenous glycoprotein, laminin, from a mouse tumor that
produces basement membrane. The protein consists of at least two polypeptide chains (Mr = …

Bisphosphonate drugs inhibit osteoclastic bone resorption and are widely used to treat
skeletal complications in patients with tumor-induced osteolysis. We now show that zoledronic …

Acquisition of invasive/metastatic potential through protease expression is an essential
event in tumor progression. High levels of components of the plasminogen activation system, …

Several growth factors such as vascular endothelial growth factor (VEGF)-A and placental
growth factor (PlGF) are involved in the placental vascular development. We investigated …

Relapsing polychondritis is a disorder of unknown cause characterized by the destruction of
cartilage. To test the hypothesis that immunologic mechanisms are involved in the …

OBJECTIVE: A large trial published in 2000 concluded that planned vaginal delivery of term
breech births is associated with high neonatal risks. Because the obstetric practices in that …