To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

In addition to their pivotal role in thrombosis and wound repair, platelets participate in
inflammatory responses. We investigated the role of platelets in the autoimmune disease …

Twenty-eight patients with refractory rheumatoid arthritis completed a randomized 24-week
double-blind crossover trial comparing oral methotrexate (2.5 to 5 mg every 12 hours for …

CD4 + T cells are central mediators of autoimmune pathology; however, defining their key
effector functions in specific autoimmune diseases remains challenging. Pathogenic CD4 + T …

To identify rheumatoid arthritis risk loci in European populations, we conducted a meta-analysis
of two published genome-wide association (GWA) studies totaling 3,393 cases and …

To identify susceptibility alleles associated with rheumatoid arthritis, we genotyped 397
individuals with rheumatoid arthritis for 116,204 SNPs and carried out an association analysis in …

To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs
from 179 independent loci with P < 0.001 in a published meta-analysis of RA genome-wide …

Objective To examine the safety and pharmacokinetics of and clinical response to leflunomide,
a de novo pyrimidine synthesis inhibitor, when administered to patients with active …

Phospholipase A 2 (PLA 2 ) catalyses the release of arachidonic acid for generation of lipid
mediators of inflammation and is crucial in diverse inflammatory processes. The functions of …

Twelve patients with active rheumatoid arthritis supplemented their usual diet with 20 gm of
Max‐EPA fish oil, daily, for 6 weeks. Following this supplementation, the ratio of arachidonic …