Methods. All patients had participated in the 56-week COBRA trial. During followup, they were
seen by their own rheumatologists and were also assessed regularly by study nurses; no …

Background The value of intensive combination therapy in early rheumatoid arthritis is
unproven. In a multicentre, double-blind, randomised trial (COBRA), we compared the …

Objectives: Correlation of serum trough infliximab levels and antibodies to infliximab (anti-infliximab)
with clinical response in ankylosing spondylitis. Methods: In accordance with the …

Background: Immunogenicity, specifically the onset of antibodies against tumour necrosis
factor (TNF) blocking agents, seems to play an important role in non-response to treatment …

Background COBRA (for ‘COmbinatie therapie Bij Rheumatoide Artritis’) combination therapy
is effective for the treatment of rheumatoid arthritis (RA), but long-term safety is unknown. …

Objective: To assess the efficacy and safety of leflunomide in active ankylosing spondylitis (AS)
compared with placebo in a 24 week pilot study. Methods: In a single centre randomised, …

Treatment with anti-tumour necrosis factor (TNF) is very effective in most patients with
ankylosing spondylitis (AS), but inefficacy occurs in about 40% of cases. 1 Antibody formation …

Objective. To investigate whether use of adalimumab decreases the frequency of attacks of
anterior uveitis (AU) in patients with ankylosing spondylitis (AS). Methods. Consecutive …

Introduction Positron Emission Tomography - Computer Tomography (PET-CT) is an interesting
imaging technique to visualize Ankylosing Spondylitis (AS) activity using specific PET …

Introduction Ankylosing Spondylitis (AS) is characterised by limitations in physical function.
The Bath Ankylosing Spondylitis Functional Index (BASFI) is considered to be the gold-…