Importance Idiopathic inflammatory myopathies are heterogeneous in their pathophysiologic
features and prognosis. The emergence of myositis-specific autoantibodies suggests that …

Necrotizing autoimmune myopathy (NAM) is a group of acquired myopathies characterized
by prominent myofiber necrosis with little or no muscle inflammation. Recently, researchers …

Cancer can occur in patients with inflammatory myopathies. This association is mainly
observed in dermatomyositis, and myositis-specific antibodies have allowed us to delineate …

Objective Anti–signal recognition particle (anti‐SRP) autoantibodies are associated with
severe acquired necrotizing myopathies. The role of these autoantibodies remains elusive, and …

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal
recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs) …

Anti-Ku antibodies have been reported in a wide spectrum of autoimmune diseases, sometimes
in association with inflammatory myopathies (IM). We studied the clinical, laboratory, …

Objective To evaluate the efficacy and safety of Janus kinase inhibitors (JAKis) in JDM.
Methods We conducted a single-centre retrospective study of patients with JDM treated by JAKi …

The anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody is specifically
associated with dermatomyositis (DM). Nevertheless, anti–MDA5 + -patients experience …

Objective. To analyze the clinical value of anti-DFS70 antibodies in a cohort of patients
undergoing routine antinuclear antibodies (ANAs) testing. Methods. Sera with a dense fine …

Sir, We read with interest the article by Ladislau et al.(2018), highlighting the key role of type
I interferon (IFN) in the pathophysiology of the muscle disease observed in dermatomyositis …