Background: Effective treatment of active rheumatoid arthritis (RA) requires early diagnosis
and early disease modifying antirheumatic drug (DMARD) treatment to have an impact on …

Systemic lupus erythematosus (SLE) is a multifactorial disease and its pathogenesis and
precise aetiology remain unknown. Under physiological conditions, neither apoptotic nor …

It has been suggested that rheumatoid inflammation is mediated by activated pro-inflammatory
T helper type I cells. In contrast, immunomodulatory T helper type 2 cells and their …

Background Neutralization of tumor necrosis factor α (TNF-α) for three to six months reduces
the symptoms and signs of rheumatoid arthritis. However, the capacity of this approach to …

Apoptotic cell death is important in the development and homeostasis of multicellular organisms
1 and is a highly controlled means of eliminating dangerous, damaged or unnecessary …

Tumour necrosis factor α (TNFα) is a critical inflammatory mediator in rheumatoid arthritis,
and may therefore be a useful target for specific immunotherapy. In support of this hypothesis, …

Objective To evaluate the efficacy, pharmacokinetics, immunogenicity, and safety of multiple
infusions of a chimeric monoclonal anti‐tumor necrosis factor α antibody (cA2) (infliximab; …

Objective. Different sets of diagnostic criteria have been proposed for Sjögren's syndrome (SS),
but none have been validated with a large series of patients or in a multicenter study. We …

Objective. The objective of this study was to verify the usefulness of a simple disease activity
index (SDAI) for rheumatoid arthritis (RA). Methods. The SDAI is the numerical sum of five …

… Clair, van der Heijde, Smolen, Maini, Bathon, Emery, Keystone, and Kalden have received
consultancies and/or honoraria from Centocor, Inc., totaling less than $10,000 per year. In …