The serine/threonine kinase Akt/PKB pathway presents an exciting new target for molecular
therapeutics, as it functions as a cardinal nodal point for transducing extracellular (growth …

Objectives : The aim of this study was to evaluate the effect of statins in decreasing cardiovascular
events in women and men. Background : Published data reviews have suggested that …

… Nobori, & JQ Cheng: Positive feedback regulation between Akt2 and MyoD during
muscle differentiation: Cloning of Akt2 promoter. J Biol Chem 277, 23230-23235 (2002) 23. …

MicroRNAs (miRNA) represent a novel class of genes that function as negative regulators of
gene expression. Recently, miRNAs have been implicated in several cancers. However, …

… For Southern-blot analysis of AKT2 amplification, we employed a 2-kbp BamHI-SmaI
genomic fragment of AKT2 (Cheng et a[., 1992). Under high stringency conditions, this probe …

We previously demonstrated that the putative oncogene AKT2 is amplified and overexpressed
in some human ovarian carcinomas. We have now identified amplification of AKT2 in …

Autophagy is an evolutionarily conserved 'self-eating' process. Although the genes essential
for autophagy (named Atg) have been identified in yeast, the molecular mechanism of how …

We isolated cDNA clones containing the entire coding region of the putative oncogene AKT2.
Sequence analysis and in vitro translation demonstrated that AKT2 encodes a 56-kDa …

Transforming growth factor β (TGF-β) signaling facilitates metastasis in advanced malignancy.
While a number of protein-encoding genes are known to be involved in this process, …

Vascular endothelial growth factor (VEGF) upregulation is induced by many receptor and
intracellular oncogenic proteins commonly activated in cancer, rendering molecular targeting …