Elevated cerebral blood flow and volume in systemic lupus measured by dynamic susceptibility contrast magnetic resonance imaging

…, WL Sibbitt, CR Qualls, PG Mullins, JM Sharrar… - The Journal of …, 2010 - jrheum.org
Objective. Studies that have examined abnormalities in cerebral blood flow (CBF) in patients
with systemic lupus erythematosus (SLE) reported CBF relative to a region assumed to be …

Middle cerebral artery blood flows by combining TCD velocities and MRA diameters: in vitro and in vivo validations

KA Yonan, ER Greene, JM Sharrar, A Caprihan… - Ultrasound in medicine …, 2014 - Elsevier
Non-invasive transcranial Doppler (TCD) is widely used for blood velocity (BV, cm/sec)
measurements in the human middle cerebral artery (MCA). MCABV measurements are accepted …

Middle cerebral artery resistivity and pulsatility indices in systemic lupus erythematosus: evidence for hyperperfusion

ER Greene, KA Yonan, JM Sharrar, WL Sibbitt Jr… - Lupus, 2012 - journals.sagepub.com
Background and purpose: Systemic lupus erythematosus (SLE) is associated with significant
cerebrovascular and neuropsychiatric disease for which multiple pathogeneses have been …

Decreased arterial distensibility in patients with systemic lupus erythematosus

KR Lanphere, JM Sharrar, WL Sibbitt… - The FASEB …, 2009 - Wiley Online Library
Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease that is atherogenic.
Arterial distensibility (AD) is a risk factor and an independent predictor of cardiovascular …

[HTML][HTML] Clades of huge phages from across Earth's ecosystems

…, C Sun, DSA Goltsman, MA Borton, A Sharrar… - Nature, 2020 - nature.com
Bacteriophages typically have small genomes 1 and depend on their bacterial hosts for
replication 2 . Here we sequenced DNA from diverse ecosystems and found hundreds of phage …

Varicella vaccine exposure during pregnancy: data from the first 5 years of the pregnancy registry

KE Shields, K Galil, J Seward, RG Sharrar… - Obstetrics & …, 2001 - journals.lww.com
OBJECTIVE To assess the risks of congenital varicella syndrome and other birth defects in
offspring of women who inadvertently received varicella vaccine during pregnancy or within 3 …

[PDF][PDF] Closely related Lak megaphages replicate in the microbiomes of diverse animals

…, AL Borges, N Bordin, R Sachdeva, A Tett, AM Sharrar… - Iscience, 2021 - cell.com
Lak phages with alternatively coded ∼540 kbp genomes were recently reported to replicate
in Prevotella in microbiomes of humans that consume a non-Western diet, baboons, and …

[HTML][HTML] Discovery and engineering of AiEvo2, a novel Cas12a nuclease for human gene editing applications

A Sharrar, LA de Tacca, Z Meacham… - Journal of Biological …, 2024 - ASBMB
The precision of gene editing technology is critical to creating safe and effective therapies for
treating human disease. While the programmability of CRISPR–Cas systems has allowed …

Legionnaires' disease: description of an epidemic of pneumonia

…, WE Parkin, HJ Beecham, RG Sharrar… - … England Journal of …, 1977 - Mass Medical Soc
An explosive, common-source outbreak of pneumonia caused by a previously unrecognized
bacterium affected primarily persons attending an American Legion convention in …

The postmarketing safety profile of varicella vaccine

RG Sharrar, P LaRussa, SA Galea, SP Steinberg… - Vaccine, 2000 - Elsevier
… LaRussa P, Steinberg S, Sharrar R, Galea S, Gershon A. Identification and differentiation
of wild (WT)- and vaccine (OKA)-strain VZV isolates by PCR from recipients of live attenuated …