Asymmetric synthesis of active pharmaceutical ingredients
…, JT Reeves, CH Senanayake, JJ Song - Chemical …, 2006 - ACS Publications
Recent trends in the pharmaceutical industry demonstrate that the number of new chemical
entities (NCEs) launched on the market each year has been steadily declining over the last …
entities (NCEs) launched on the market each year has been steadily declining over the last …
Organ engineering based on decellularized matrix scaffolds
End-organ failure is one of the major healthcare challenges in the Western world. Yet, donor
organ shortage and the need for immunosuppression limit the impact of transplantation. …
organ shortage and the need for immunosuppression limit the impact of transplantation. …
The growing impact of catalysis in the pharmaceutical industry
CA Busacca, DR Fandrick, JJ Song… - Advanced Synthesis …, 2011 - Wiley Online Library
… Song’s research interests concern the discovery of new synthetic methodologies and their
applications to the development of practical and economical synthesis of biologically active …
applications to the development of practical and economical synthesis of biologically active …
Argonaute2 is the catalytic engine of mammalian RNAi
…, FV Rivas, CG Marsden, JM Thomson, JJ Song… - Science, 2004 - science.org
Gene silencing through RNA interference (RNAi) is carried out by RISC, the RNA-induced
silencing complex. RISC contains two signature components, small interfering RNAs (siRNAs) …
silencing complex. RISC contains two signature components, small interfering RNAs (siRNAs) …
Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
To equalize X-chromosome dosages between the sexes, the female mammal inactivates one
of her two X chromosomes. X-chromosome inactivation (XCI) is initiated by expression of …
of her two X chromosomes. X-chromosome inactivation (XCI) is initiated by expression of …
Crystal structure of Argonaute and its implications for RISC slicer activity
JJ Song, SK Smith, GJ Hannon, L Joshua-Tor - science, 2004 - science.org
Argonaute proteins and small interfering RNAs (siRNAs) are the known signature
components of the RNA interference effector complex RNA-induced silencing complex (RISC). …
components of the RNA interference effector complex RNA-induced silencing complex (RISC). …
Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile
…, A Sabnis, E Schnipper, JJ Song, YH Song… - Science translational …, 2012 - science.org
We describe the development and clinical translation of a targeted polymeric nanoparticle (TNP)
containing the chemotherapeutic docetaxel (DTXL) for the treatment of patients with …
containing the chemotherapeutic docetaxel (DTXL) for the treatment of patients with …
[PDF][PDF] Genome-wide identification of polycomb-associated RNAs by RIP-seq
…, JT Kung, Y Ogawa, DJ Grau, K Sarma, JJ Song… - Molecular cell, 2010 - cell.com
Polycomb proteins play essential roles in stem cell renewal and human disease. Recent
studies of HOX genes and X inactivation have provided evidence for RNA cofactors in …
studies of HOX genes and X inactivation have provided evidence for RNA cofactors in …
Regeneration and experimental orthotopic transplantation of a bioengineered kidney
… JJS and JPG performed animal surgeries, conducted decellularization and whole-organ
culture experiments and performed in vitro and in vivo testing. SEG was responsible for cell …
culture experiments and performed in vitro and in vivo testing. SEG was responsible for cell …
Purified Argonaute2 and an siRNA form recombinant human RISC
FV Rivas, NH Tolia, JJ Song, JP Aragon, J Liu… - Nature structural & …, 2005 - nature.com
Genetic, biochemical and structural studies have implicated Argonaute proteins as the
catalytic core of the RNAi effector complex, RISC. Here we show that recombinant, human …
catalytic core of the RNAi effector complex, RISC. Here we show that recombinant, human …