A lack of regulatory T (T Reg ) cells that express CD4, CD25 and forkhead box P3 (FOXP3)
results in severe autoimmunity in both mice and humans. Since the discovery of T Reg cells, …

Regulatory T cells (Treg) play a dominant role in suppression of autoimmune pathology, as
rescue of Treg number and/or function in model systems can both prevent and reverse …

Individuals at high risk of developing seropositive rheumatoid arthritis (RA) can be identified
for translational research and disease prevention studies through the presence of highly …

CD4 + CD25 + regulatory T (T R ) cells have been described in both humans and mice. In
mice, T R are thymically derived, and lack of T R leads to organ-specific autoimmunity. …

Type 1 diabetes (T1D) is an autoimmune disease that occurs in genetically susceptible
individuals. Regulatory T cells (T regs ) have been shown to be defective in the autoimmune …

Complement receptor 2–negative (CR2/CD21 − ) B cells have been found enriched in patients
with autoimmune diseases and in common variable immunodeficiency (CVID) patients …

A variant of the PTPN22 gene, 1858C/T, is associated with an increased risk for the
development of a wide array of autoimmune disorders. It is known that the protein tyrosine …

The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for
mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity that …

Defects in immune regulation have been implicated in the pathogenesis of diabetes in mouse
and in man. In vitro assays using autologous regulatory (Treg) and responder effector (Teff…

OBJECTIVE In humans, multiple genes in the interleukin (IL)-2/IL-2 receptor (IL-2R) pathway
are associated with type 1 diabetes. However, no link between IL-2 responsiveness and …