[HTML][HTML] The role of reactive oxygen species in apoptosis of the diabetic kidney
F Wagener, D Dekker, JH Berden, A Scharstuhl… - Apoptosis, 2009 - Springer
Increased levels of reactive oxygen species (ROS) by hyperglycemia can induce apoptosis
of renal cells and diabetic nephropathy. The redox balance in the renal cell seems, therefore, …
of renal cells and diabetic nephropathy. The redox balance in the renal cell seems, therefore, …
[HTML][HTML] Heparanase in glomerular diseases
…, AL Rops, I Vlodavsky, V Levidiotis, JH Berden… - Kidney international, 2007 - Elsevier
Heparanase is an endo-β(1–4)-D-glucuronidase that degrades heparan sulfate (HS)
polysaccharide side chains. The role of heparanase in metastasis, angiogenesis, and inflammation …
polysaccharide side chains. The role of heparanase in metastasis, angiogenesis, and inflammation …
[HTML][HTML] The role of dendritic cells in the pathogenesis of systemic lupus erythematosus
…, J van der Vlag, J Ruben, GJ Adema, JH Berden… - Arthritis research & …, 2010 - Springer
The etiology of the autoimmune disease systemic lupus erythematosus is not known, but
aberrant apoptosis and/or insufficient clearance of apoptotic material have been assigned a …
aberrant apoptosis and/or insufficient clearance of apoptotic material have been assigned a …
Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity
…, AL Rops, J Van Der Vlag, JH Berden… - The American journal of …, 2007 - Elsevier
Glomerular charge selectivity has been attributed to anionic heparan sulfate proteoglycans (HSPGs)
in the glomerular basement membrane (GBM). Agrin is the predominant GBM-HSPG…
in the glomerular basement membrane (GBM). Agrin is the predominant GBM-HSPG…
Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo.
…, KJ Assmann, RJ Smeenk, JH Berden - The Journal of …, 1994 - Am Soc Clin Investig
… van den Born and Dr Berden are supported by a grant from the EC Biomed I program (BMH1…
Heuvel, MAH Bakker, JH Veerkamp, KJM Assmann, and JHM Berden. 1992. A monoclonal …
Heuvel, MAH Bakker, JH Veerkamp, KJM Assmann, and JHM Berden. 1992. A monoclonal …
[HTML][HTML] Increased expression of heparanase in overt diabetic nephropathy
…, E Zcharia, I Vlodavsky, J Van Der Vlag, JH Berden - Kidney international, 2006 - Elsevier
In overt diabetic nephropathy (DNP), an increase in the permeability of the glomerular
basement membrane (GBM) has been associated with a loss of negatively charged heparan …
basement membrane (GBM) has been associated with a loss of negatively charged heparan …
Circulating apoptotic microparticles in systemic lupus erythematosus patients drive the activation of dendritic cell subsets and prime neutrophils for NETosis
…, J Fransen, HBPM Dijkman, JH Berden… - Arthritis & …, 2016 - Wiley Online Library
Objective Circulating chromatin‐containing apoptotic material and/or neutrophil extracellular
traps (NETs) have been proposed to be an important driving force for the antichromatin …
traps (NETs) have been proposed to be an important driving force for the antichromatin …
[HTML][HTML] Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a …
…, A Ma, P Rogers, LJ Mason, JH Berden… - Arthritis research & …, 2009 - Springer
Introduction Glomerulonephritis is a major cause of morbidity and mortality in patients with
systemic lupus erythematosus (SLE). Deposition of autoantibodies in the glomeruli plays a …
systemic lupus erythematosus (SLE). Deposition of autoantibodies in the glomeruli plays a …
Cross-reactivity of human and murine anti-DNA antibodies with heparan sulfate. The major glycosaminoglycan in glomerular basement membranes.
…, LB Van de Putte, PJ Capel, JH Berden - The Journal of …, 1986 - Am Soc Clin Investig
In 30 of 33 human systemic lupus erythematosus (SLE) sera and in 10 sera from MRL/l mice
with spontaneous SLE, antibodies against heparan sulfate were detected. The anti-heparan …
with spontaneous SLE, antibodies against heparan sulfate were detected. The anti-heparan …
Apoptosis‐induced acetylation of histones is pathogenic in systemic lupus erythematosus
…, CW Jacobs, S Muller, JH Berden… - Arthritis & …, 2007 - Wiley Online Library
Objective In systemic lupus erythematosus (SLE), inadequate removal of apoptotic cells may
lead to challenge of the immune system with immunogenic self antigens that have been …
lead to challenge of the immune system with immunogenic self antigens that have been …