[HTML][HTML] Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome

RJ Torres, JG Puig - Orphanet journal of rare diseases, 2007 - Springer
Deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT) activity is an inborn
error of purine metabolism associated with uric acid overproduction and a continuum …

Uric acid and oxidative stress: relative impact on cardiovascular risk

P Strazzullo, JG Puig - Nutrition, Metabolism and Cardiovascular Diseases, 2007 - Elsevier
Post-hoc analyses of the GREACE and the LIFE trials have renewed the interest in elevated
serum uric acid (SUA) as a factor contributing to atherosclerotic cardiovascular disease (…

Hyperuricemia, gout and the metabolic syndrome

JG Puig, MA Martinez - Current opinion in rheumatology, 2008 - journals.lww.com
… 30 Puig JG, Ruilope LM. Uric acid as a cardiovascular risk factor in arterial hypertension. J …
31• Strazzullo P, Puig JG. Uric acid and oxidative stress: relative impact on cardiovascular risk…

Equivalence of indapamide SR and enalapril on microalbuminuria reduction in hypertensive patients with type 2 diabetes: The NESTOR* study

M Marre, JG Puig, F Kokot, M Fernandez… - Journal of …, 2004 - journals.lww.com
Objectives To test whether microalbuminuria in patients with type 2 diabetes and hypertension
is primarily dependent on the severity of hypertension, and to compare the effectiveness …

Delineation of the motor disorder of Lesch–Nyhan disease

…, W Nyhan, R De Kremer, GE Eddey, JG Puig… - Brain, 2006 - academic.oup.com
Lesch–Nyhan disease (LND) is caused by deficiency of the purine salvage enzyme
hypoxanthine-guanine phosphoribosyltransferase (HPRT). Affected individuals exhibit over-…

Sex differences in uric acid metabolism in adults: evidence for a lack of influence of estradiol-17β (E2) on the renal handling of urate

FM Antón, JG Puig, T Ramos, P González, J Ordás - Metabolism, 1986 - Elsevier
The serum urate concentration of adult women, which is lower than in men of a similar age,
is thought to be related to a higher renal clearance of urate in women, possibly due to their …

Diagnosis of gout in patients with asymptomatic hyperuricaemia: a pilot ultrasound study

E De Miguel, JG Puig, C Castillo, D Peiteado… - Annals of the …, 2011 - ard.bmj.com
Asymptomatic hyperuricaemia is defined as a serum urate concentration equal to or above
7.0 mg/dl with no symptoms or clinical signs. Most individuals with hyperuricaemia, however, …

Uric acid as a cardiovascular risk factor in arterial hypertension

JG Puig, LM Ruilope - Journal of hypertension, 1999 - journals.lww.com
Background Increased serum urate concentrations is a frequent finding in patients with
hypertension. Since hyperuricaemia is associated with obesity, renal disease, hyperlipidaemia, …

Female gout: clinical spectrum and uric acid metabolism

JG Puig, AD Michán, ML Jiménez… - Archives of internal …, 1991 - jamanetwork.com
We reviewed the clinical features and uric acid metabolism in 37 female patients with gout.
In 32 female patients (86%), gout was diagnosed after menopause. Among the five …

Asymptomatic hyperuricemia: impact of ultrasonography

JG Puig, E De Miguel, MC Castillo… - … , and Nucleic Acids, 2008 - Taylor & Francis
Thirty-five patients (23 males) with asymptomatic hyperuricemia for at least two years underwent
two-dimensioal ultrasonography of knees and ankles. Urate deposits (tophi) in tendons, …