Background Reaching the therapeutic target of remission or low-disease activity has
improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target …

Interleukin-6 (IL-6) is a cytokine that can facilitate autoimmune phenomena, amplify acute
inflammation and promote the evolution into a chronic inflammatory state. In addition, it is a …

Objectives To provide an update of the EULAR rheumatoid arthritis (RA) management
recommendations addressing the most recent developments in the field. Methods An international …

Bone is constantly being remodelled in a dynamic process where osteoblasts are
responsible for bone formation and osteoclasts for its resorption. Osteoblasts are specialized …

Background During the transition to rheumatoid arthritis (RA) many patients pass through a
phase characterised by the presence of symptoms without clinically apparent synovitis. …

Rheumatoid arthritis is the most common inflammatory joint disease. The etiopathogenesis
of this condition has been classically explained by a T cell-driven process. However, recent …

One of the most serious presentations of preeclampsia is the HELLP (hemolysis, elevated
liver enzymes, low platelets) syndrome. Treatment has generally been limited to supportive …

The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis.
The study of synovial tissue has advanced considerably throughout the past few decades …

The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case …

Rheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It
is associated with significant burden at the patient and societal level. Extensive efforts have …