A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell
model for tumor development and progression. The meeting participants were charged with …

Genetic analyses have shaped much of our understanding of cancer. However, it is becoming
increasingly clear that cancer cells display features of normal tissue organization, where …

Although uncontrolled proliferation is a distinguishing property of a tumor as a whole, the
individual cells that make up the tumor exhibit considerable variation in many properties, …

On the subject of acute myeloid leukemia (AML), there is little consensus about the target cell
within the hematopoietic stem cell hierarchy that is susceptible to leukemic transformation, …

MOST human acute myeloid leukaemia (AML) cells have limited proliferative capacity,
suggesting that the leukaemic clone may be maintained by a rare population of stem cells 1–5 . …

… Hedley for advice on establishment of the xenograft model, J Wang for assistance with
manuscript preparation, and the Dick laboratory members, P. Dirks and D.Hill for comments on …

Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy
of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases …

… Dick … & Dick, JE Hematopoiesis: a human perspective. Cell Stem Cell 10, 120–136 (2012) …
We thank all members of the Dick laboratory for critical assessment of this work, A. Khandani, P…

… Minden for providing AML samples, and members of the Dick laboratory and T. Lapidot
for critical comments on the manuscript. This work was supported by a Canadian Institutes of …

Emerging evidence suggests cancer stem cells sustain neoplasms; however, little is understood
of the normal cell initially targeted and the resultant cancer stem cells. We show here, by …