Although the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, or statins, share
a common lipid-lowering effect, there are differences within this class of drugs. The low-…

Purpose Treatment guidelines recommend insulin progression (switching from basal to a
premixed insulin regimen, adding bolus doses, and/or increasing dosing frequency) to achieve …

… John D Seeger, PharmD John D Seeger … HK Choi, MA Hernán, JD Seeger, JM Robins,
and F Wolfe conceived and designed the study, did data management and statistical analyses, …

Comorbidity is an important confounder in epidemiologic studies. The authors compared
the predictive performance of comorbidity scores for use in epidemiologic research with …

… Johannes CB, Koro CE, Quinn SG, Cutone JA, Seeger JD. The risk of coronary heart
disease in type 2 diabetic patients exposed to thiazolidinediones compared to metformin and …

Background Aprotinin (Trasylol) is used to mitigate bleeding during coronary-artery bypass
grafting (CABG). Accumulating evidence suggests that this practice increases mortality. …

Background Several passive surveillance systems reported increased risks of myocarditis or
pericarditis, or both, after COVID-19 mRNA vaccination, especially in young men. We used …

Full article: Use of a claims-based active drug safety surveillance system to assess the risk
of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide Skip to …

OBJECTIVE: The oral contraceptive ethinylestradiol 0.03 mg/drospirenone 3 mg contains a
progestin component that differs from other oral contraceptives. Case reports and …

Background . Previous observational studies found highly active antiretroviral therapy (HAART)
to be associated with improved survival among human immunodeficiency virus (HIV)– …