Background For children with sickle cell anaemia and high transcranial doppler (TCD) flow
velocities, regular blood transfusions can effectively prevent primary stroke, but must be …

Background Pyruvate kinase deficiency is a rare, hereditary, chronic condition that is associated
with hemolytic anemia. In a phase 2 study, mitapivat, an oral, first-in-class activator of …

An international, multicenter registry was established to collect retrospective and prospective
clinical data on patients with pyruvate kinase (PK) deficiency, the most common glycolytic …

The honey bee, Apis mellifera, pollinates a wide variety of essential crops in numerous
ecosystems around the world but faces many modern challenges. Among these, the …

Municipal wastewater provides an integrated sample of a diversity of human-associated
microbes across a sewershed, including viruses. Wastewater-based epidemiology (WBE) is a …

Objective. Raynaud’s phenomenon (RP) is an important clinical feature of systemic sclerosis
(SSc) for which consistently effective therapies are lacking. The study was designed to …

… Rothman in partial fulfillment of the requirements for a Ph.D. degree from the University of …
(103) and Rothman et al. (104). We incorporated the 16S rRNA gene primer sequence, unique …

Bumble bees are important and widespread insect pollinators who face many environmental
challenges. For example, bees are exposed to the metalloid selenate when foraging on …

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with isolated
thrombocytopenia and hemorrhagic risk. While many children with ITP can be safely observed, …

Bumblebees (Bombus spp.) are important and widespread insect pollinators, but the act of
foraging on flowers can expose them to harmful pesticides and chemicals such as oxidizers …